BRD-K59469039_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K59469039_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADGRG6 adhesion G protein-coupled receptor G6
AHR aryl hydrocarbon receptor
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
BCL6 B-cell CLL/lymphoma 6
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHRDL1 chordin-like 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOXO3 forkhead box O3
GARS glycyl-tRNA synthetase
GREB1 growth regulation by estrogen in breast cancer 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGB2 high mobility group box 2
HOPX HOP homeobox
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MPZL2 myelin protein zero-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G16 phospholipase A2, group XVI
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROM1 prominin 1
PSAP prosaposin
PSPH phosphoserine phosphatase
RHOQ ras homolog family member Q
RND3 Rho family GTPase 3
SERTAD2 SERTA domain containing 2
SMAD3 SMAD family member 3
TFRC transferrin receptor
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATF5 activating transcription factor 5
AZU1 azurocidin 1
CA12 carbonic anhydrase XII
CGA glycoprotein hormones, alpha polypeptide
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
COL5A1 collagen, type V, alpha 1
EFNB2 ephrin-B2
HP haptoglobin
HSPA1A heat shock 70kDa protein 1A
IGFBP5 insulin-like growth factor binding protein 5
KCTD12 potassium channel tetramerization domain containing 12
MSRB1 methionine sulfoxide reductase B1
PDGFA platelet-derived growth factor alpha polypeptide
SLPI secretory leukocyte peptidase inhibitor
SPINK1 serine peptidase inhibitor, Kazal type 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
Funding