BRD-K59705555_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K59705555_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CCL4 chemokine (C-C motif) ligand 4
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDC42 cell division cycle 42
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLDN4 claudin 4
CXCL9 chemokine (C-X-C motif) ligand 9
DUSP2 dual specificity phosphatase 2
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EZR ezrin
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP7 fatty acid binding protein 7, brain
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GBP1 guanylate binding protein 1, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GEM GTP binding protein overexpressed in skeletal muscle
GPM6B glycoprotein M6B
GSTA1 glutathione S-transferase alpha 1
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HILPDA hypoxia inducible lipid droplet-associated
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IL32 interleukin 32
IRF1 interferon regulatory factor 1
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF6 Kruppel-like factor 6
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
LIF leukemia inhibitory factor
LIMA1 LIM domain and actin binding 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MPZL2 myelin protein zero-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NES nestin
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLBD1 phospholipase B domain containing 1
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TCF4 transcription factor 4
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WEE1 WEE1 G2 checkpoint kinase
WISP2 WNT1 inducible signaling pathway protein 2
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
AGTR1 angiotensin II receptor, type 1
ALCAM activated leukocyte cell adhesion molecule
ATF5 activating transcription factor 5
BASP1 brain abundant, membrane attached signal protein 1
BRCA1 breast cancer 1, early onset
CDC25B cell division cycle 25B
CDKN2A cyclin-dependent kinase inhibitor 2A
CIAPIN1 cytokine induced apoptosis inhibitor 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EED embryonic ectoderm development
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
F5 coagulation factor V (proaccelerin, labile factor)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPER1 G protein-coupled estrogen receptor 1
H2AFV H2A histone family, member V
HELLS helicase, lymphoid-specific
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IFI44 interferon-induced protein 44
KIAA0907 KIAA0907
KIF14 kinesin family member 14
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LONP2 lon peptidase 2, peroxisomal
MTDH metadherin
NME4 NME/NM23 nucleoside diphosphate kinase 4
PCGF2 polycomb group ring finger 2
PCP4 Purkinje cell protein 4
PCTP phosphatidylcholine transfer protein
PLAC8 placenta-specific 8
PRAME preferentially expressed antigen in melanoma
PRKCA protein kinase C, alpha
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PXMP2 peroxisomal membrane protein 2, 22kDa
RASA4 RAS p21 protein activator 4
RPS11 ribosomal protein S11
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SORD sorbitol dehydrogenase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
THAP11 THAP domain containing 11
TPBG trophoblast glycoprotein
TRAK2 trafficking protein, kinesin binding 2
TRAPPC3 trafficking protein particle complex 3
TSPYL5 TSPY-like 5
UNC119B unc-119 homolog B (C. elegans)
VCAN versican
ZNF318 zinc finger protein 318
Funding