BRD-K60070073_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

227 genes differentially expressed following the BRD-K60070073_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP9A ATPase, class II, type 9A
BAG3 BCL2-associated athanogene 3
BGN biglycan
BLVRB biliverdin reductase B
CA2 carbonic anhydrase II
CANX calnexin
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL1A1 collagen, type I, alpha 1
COL8A2 collagen, type VIII, alpha 2
CPM carboxypeptidase M
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
EGFL6 EGF-like-domain, multiple 6
EIF1 eukaryotic translation initiation factor 1
EPRS glutamyl-prolyl-tRNA synthetase
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HPSE heparanase
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
HYOU1 hypoxia up-regulated 1
IFRD1 interferon-related developmental regulator 1
INHBE inhibin, beta E
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF4 Kruppel-like factor 4 (gut)
LARP6 La ribonucleoprotein domain family, member 6
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NPC1 Niemann-Pick disease, type C1
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZD8 PDZ domain containing 8
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PYCR1 pyrroline-5-carboxylate reductase 1
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RNF114 ring finger protein 114
RNMT RNA (guanine-7-) methyltransferase
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SDF2L1 stromal cell-derived factor 2-like 1
SEC63 SEC63 homolog (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
SRGN serglycin
STC2 stanniocalcin 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TES testin LIM domain protein
TRIB3 tribbles pseudokinase 3
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)
UGDH UDP-glucose 6-dehydrogenase
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ALB albumin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CENPA centromere protein A
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP4 dual specificity phosphatase 4
EDNRB endothelin receptor type B
EHBP1 EH domain binding protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA3 EPH receptor A3
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FAM216A family with sequence similarity 216, member A
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GRWD1 glutamate-rich WD repeat containing 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFI44 interferon-induced protein 44
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGSF3 immunoglobulin superfamily, member 3
IL1RN interleukin 1 receptor antagonist
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KIF20A kinesin family member 20A
LAMA4 laminin, alpha 4
LAMC1 laminin, gamma 1 (formerly LAMB2)
LEPR leptin receptor
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MOK MOK protein kinase
MSL1 male-specific lethal 1 homolog (Drosophila)
NFIB nuclear factor I/B
NRN1 neuritin 1
NUSAP1 nucleolar and spindle associated protein 1
OLFM1 olfactomedin 1
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
PLN phospholamban
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
PSCA prostate stem cell antigen
PSPH phosphoserine phosphatase
PSRC1 proline/serine-rich coiled-coil 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SDC2 syndecan 2
SFRP1 secreted frizzled-related protein 1
SMAD3 SMAD family member 3
SOX11 SRY (sex determining region Y)-box 11
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
STARD13 StAR-related lipid transfer (START) domain containing 13
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TSEN2 TSEN2 tRNA splicing endonuclease subunit