BRD-K60230970_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K60230970_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CD163 CD163 molecule
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSZ cathepsin Z
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSE dermatan sulfate epimerase
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FGL2 fibrinogen-like 2
FOXG1 forkhead box G1
FPR3 formyl peptide receptor 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGKV4-1 immunoglobulin kappa variable 4-1
IL1R2 interleukin 1 receptor, type II
INSM1 insulinoma-associated 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JUN jun proto-oncogene
LTF lactotransferrin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MUC5B mucin 5B, oligomeric mucus/gel-forming
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS2 regulator of G-protein signaling 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPINK1 serine peptidase inhibitor, Kazal type 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APMAP adipocyte plasma membrane associated protein
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
B3GNT1
BIK BCL2-interacting killer (apoptosis-inducing)
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CCND2 cyclin D2
CCNF cyclin F
CDK4 cyclin-dependent kinase 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUOX2 dual oxidase 2
EFNA1 ephrin-A1
EMP1 epithelial membrane protein 1
EPHA3 EPH receptor A3
ERBB3 erb-b2 receptor tyrosine kinase 3
ERLIN1 ER lipid raft associated 1
FUCA1 fucosidase, alpha-L- 1, tissue
FXYD5 FXYD domain containing ion transport regulator 5
GPRC5A G protein-coupled receptor, class C, group 5, member A
HHEX hematopoietically expressed homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGLL1 immunoglobulin lambda-like polypeptide 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IRS1 insulin receptor substrate 1
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
NFIB nuclear factor I/B
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NRN1 neuritin 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
PTCH1 patched 1
RRAGA Ras-related GTP binding A
SCAND1 SCAN domain containing 1
SDC4 syndecan 4
SMAD3 SMAD family member 3
SPTBN1 spectrin, beta, non-erythrocytic 1
SVIL supervillin
TCTA T-cell leukemia translocation altered
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TNS3 tensin 3
VSNL1 visinin-like 1
WWTR1 WW domain containing transcription regulator 1
ZCCHC24 zinc finger, CCHC domain containing 24