BRD-K60895275_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K60895275_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
APOC1 apolipoprotein C-I
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BTG2 BTG family, member 2
C3 complement component 3
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CD52 CD52 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CKS2 CDC28 protein kinase regulatory subunit 2
CNN3 calponin 3, acidic
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
CTSK cathepsin K
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
EGR1 early growth response 1
EGR3 early growth response 3
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
EZR ezrin
FILIP1L filamin A interacting protein 1-like
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GDF15 growth differentiation factor 15
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIAA0226L KIAA0226-like
KLF2 Kruppel-like factor 2
KRT23 keratin 23, type I
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLF1 myeloid leukemia factor 1
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO6 myosin VI
NAMPT nicotinamide phosphoribosyltransferase
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PRKCB protein kinase C, beta
RGS1 regulator of G-protein signaling 1
RNMT RNA (guanine-7-) methyltransferase
SIK1 salt-inducible kinase 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPST2 tyrosylprotein sulfotransferase 2
TRIB1 tribbles pseudokinase 1
VCAM1 vascular cell adhesion molecule 1
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
BASP1 brain abundant, membrane attached signal protein 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DCLK1 doublecortin-like kinase 1
DUSP4 dual specificity phosphatase 4
FGFBP1 fibroblast growth factor binding protein 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSL1 FOS-like antigen 1
FST follistatin
GSTP1 glutathione S-transferase pi 1
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
KLK11 kallikrein-related peptidase 11
KYNU kynureninase
MALL mal, T-cell differentiation protein-like
MAP1B microtubule-associated protein 1B
MRPS2 mitochondrial ribosomal protein S2
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
PDHX pyruvate dehydrogenase complex, component X
PPIF peptidylprolyl isomerase F
PTHLH parathyroid hormone-like hormone
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SDC1 syndecan 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD3 SMAD family member 3
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMF1 TATA element modulatory factor 1
TUBB tubulin, beta class I
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
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