BRD-K60932973_-666_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K60932973_-666_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
COLEC12 collectin sub-family member 12
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCR4 chemokine (C-X-C motif) receptor 4
ENO1 enolase 1, (alpha)
FKBP11 FK506 binding protein 11, 19 kDa
GAL galanin/GMAP prepropeptide
GUSBP11 glucuronidase, beta pseudogene 11
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IGLV4-60 immunoglobulin lambda variable 4-60
KCTD5 potassium channel tetramerization domain containing 5
MCOLN1 mucolipin 1
MEIS2 Meis homeobox 2
MPPED2 metallophosphoesterase domain containing 2
PDZK1IP1 PDZK1 interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POU2AF1 POU class 2 associating factor 1
S100A7 S100 calcium binding protein A7
SCD5 stearoyl-CoA desaturase 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOBP sine oculis binding protein homolog (Drosophila)
TMEM110 transmembrane protein 110
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACOT9 acyl-CoA thioesterase 9
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AGTR1 angiotensin II receptor, type 1
ANXA1 annexin A1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BAD BCL2-associated agonist of cell death
BIRC3 baculoviral IAP repeat containing 3
BTBD3 BTB (POZ) domain containing 3
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CALD1 caldesmon 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCND3 cyclin D3
CD36 CD36 molecule (thrombospondin receptor)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPU centromere protein U
CFH complement factor H
CLC Charcot-Leyden crystal galectin
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
COMP cartilage oligomeric matrix protein
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPTOR DEP domain containing MTOR-interacting protein
DLC1 DLC1 Rho GTPase activating protein
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EID1 EP300 interacting inhibitor of differentiation 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4E eukaryotic translation initiation factor 4E
ELOVL5 ELOVL fatty acid elongase 5
FABP4 fatty acid binding protein 4, adipocyte
FAM13B family with sequence similarity 13, member B
FKBP14 FK506 binding protein 14, 22 kDa
G0S2 G0/G1 switch 2
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GDF15 growth differentiation factor 15
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GRAMD3 GRAM domain containing 3
HBB hemoglobin, beta
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPB11 heat shock protein family B (small), member 11
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL13RA2 interleukin 13 receptor, alpha 2
IL6ST interleukin 6 signal transducer
ISG15 ISG15 ubiquitin-like modifier
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
LHFP lipoma HMGIC fusion partner
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LPAR1 lysophosphatidic acid receptor 1
LXN latexin
LY75 lymphocyte antigen 75
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP3L microfibrillar-associated protein 3-like
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM1 olfactomedin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PEG10 paternally expressed 10
PHF20 PHD finger protein 20
PKN2 protein kinase N2
PNMA2 paraneoplastic Ma antigen 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAP2A RAP2A, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SEH1L SEH1-like (S. cerevisiae)
SENP6 SUMO1/sentrin specific peptidase 6
SEPP1 selenoprotein P, plasma, 1
SF1 splicing factor 1
SKP1 S-phase kinase-associated protein 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP23 synaptosomal-associated protein, 23kDa
SPRY2 sprouty homolog 2 (Drosophila)
SRSF11 serine/arginine-rich splicing factor 11
STK26 serine/threonine protein kinase 26
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM47 transmembrane protein 47
TSPYL5 TSPY-like 5
UGCG UDP-glucose ceramide glucosyltransferase
Funding