BRD-K61175124_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K61175124_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASRGL1 asparaginase like 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CCNA1 cyclin A1
CHIC2 cysteine-rich hydrophobic domain 2
CLGN calmegin
CNPY3 canopy FGF signaling regulator 3
CTGF connective tissue growth factor
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUOX2 dual oxidase 2
FCGBP Fc fragment of IgG binding protein
FST follistatin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GLDC glycine dehydrogenase (decarboxylating)
GPX2 glutathione peroxidase 2
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HYOU1 hypoxia up-regulated 1
INHBE inhibin, beta E
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
KRT14 keratin 14, type I
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS methionyl-tRNA synthetase
MGP matrix Gla protein
MMP1 matrix metallopeptidase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPOX protoporphyrinogen oxidase
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RCAN1 regulator of calcineurin 1
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STK26 serine/threonine protein kinase 26
TCEA1 transcription elongation factor A (SII), 1
TDP2 tyrosyl-DNA phosphodiesterase 2
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AMACR alpha-methylacyl-CoA racemase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CDA cytidine deaminase
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
DHCR24 24-dehydrocholesterol reductase
ENDOD1 endonuclease domain containing 1
EREG epiregulin
FHOD3 formin homology 2 domain containing 3
FNBP1 formin binding protein 1
GPC4 glypican 4
GPX3 glutathione peroxidase 3
HOPX HOP homeobox
IGFBP5 insulin-like growth factor binding protein 5
IRS2 insulin receptor substrate 2
KRT4 keratin 4, type II
LRRN3 leucine rich repeat neuronal 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
PPL periplakin
RNF144A ring finger protein 144A
S100A10 S100 calcium binding protein A10
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFTPB surfactant protein B
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPTSSA serine palmitoyltransferase, small subunit A
SVIL supervillin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TP53BP2 tumor protein p53 binding protein 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZBTB16 zinc finger and BTB domain containing 16