BRD-K62221994_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K62221994_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
AK1 adenylate kinase 1
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
CCNG2 cyclin G2
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CETN2 centrin, EF-hand protein, 2
CRISP3 cysteine-rich secretory protein 3
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF5 Kruppel-like factor 5 (intestinal)
LCN2 lipocalin 2
MSMO1 methylsterol monooxygenase 1
MUC4 mucin 4, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PDE4DIP phosphodiesterase 4D interacting protein
PERP PERP, TP53 apoptosis effector
PHGDH phosphoglycerate dehydrogenase
RAD9A RAD9 homolog A (S. pombe)
S100P S100 calcium binding protein P
SEC24D SEC24 family member D
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TTN titin
UFM1 ubiquitin-fold modifier 1

decreased expression

Symbol Name
ASPN asporin
CYR61 cysteine-rich, angiogenic inducer, 61
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IL13RA2 interleukin 13 receptor, alpha 2
NEFL neurofilament, light polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMYD3 SET and MYND domain containing 3
SRSF7 serine/arginine-rich splicing factor 7
Funding