BRD-K62289640_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K62289640_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD11 ankyrin repeat domain 11
ANO1 anoctamin 1, calcium activated chloride channel
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CARS cysteinyl-tRNA synthetase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2AIP CDKN2A interacting protein
CLU clusterin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CYB5R2 cytochrome b5 reductase 2
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP1 dual specificity phosphatase 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FAM129A family with sequence similarity 129, member A
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5B G protein-coupled receptor, class C, group 5, member B
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
LAMA3 laminin, alpha 3
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEB2 melanoma antigen family B2
MAMLD1 mastermind-like domain containing 1
MAOB monoamine oxidase B
MKRN1 makorin ring finger protein 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100A6 S100 calcium binding protein A6
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SIRT1 sirtuin 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
SPON1 spondin 1, extracellular matrix protein
SQSTM1 sequestosome 1
SRRM2 serine/arginine repetitive matrix 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TANK TRAF family member-associated NFKB activator
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX3 T-box 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM41B transmembrane protein 41B
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
UVRAG UV radiation resistance associated
VCAM1 vascular cell adhesion molecule 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANGPT1 angiopoietin 1
B3GNT1
BSG basigin (Ok blood group)
C6ORF62 chromosome 6 open reading frame 62
CAPZB capping protein (actin filament) muscle Z-line, beta
CBFB core-binding factor, beta subunit
CCND1 cyclin D1
CD24 CD24 molecule
CLIC4 chloride intracellular channel 4
CLTC clathrin, heavy chain (Hc)
COX11 COX11 cytochrome c oxidase copper chaperone
CTSC cathepsin C
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAT2A methionine adenosyltransferase II, alpha
NEBL nebulette
NELL2 NEL-like 2 (chicken)
NME4 NME/NM23 nucleoside diphosphate kinase 4
PCSK6 proprotein convertase subtilisin/kexin type 6
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PXMP2 peroxisomal membrane protein 2, 22kDa
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SKAP2 src kinase associated phosphoprotein 2
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SPP1 secreted phosphoprotein 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF1 serine/arginine-rich splicing factor 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STS steroid sulfatase (microsomal), isozyme S
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TFDP1 transcription factor Dp-1
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TRIP13 thyroid hormone receptor interactor 13
TWF1 twinfilin actin binding protein 1
VAMP3 vesicle-associated membrane protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Funding