BRD-K62289640_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K62289640_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACLY ATP citrate lyase
ADIPOR2 adiponectin receptor 2
ARHGAP12 Rho GTPase activating protein 12
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BASP1 brain abundant, membrane attached signal protein 1
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CETN2 centrin, EF-hand protein, 2
CHMP1B charged multivesicular body protein 1B
CLIC4 chloride intracellular channel 4
CTH cystathionine gamma-lyase
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EAPP E2F-associated phosphoprotein
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GOLM1 golgi membrane protein 1
GSTA4 glutathione S-transferase alpha 4
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
IL1R2 interleukin 1 receptor, type II
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
IQCG IQ motif containing G
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
LDLR low density lipoprotein receptor
LIPG lipase, endothelial
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MELK maternal embryonic leucine zipper kinase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MSMO1 methylsterol monooxygenase 1
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC2 Niemann-Pick disease, type C2
NR1D2 nuclear receptor subfamily 1, group D, member 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PER1 period circadian clock 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTER phosphotriesterase related
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNMT RNA (guanine-7-) methyltransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TJP2 tight junction protein 2
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CTSB cathepsin B
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FRZB frizzled-related protein
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT13 keratin 13, type I
LYPD1 LY6/PLAUR domain containing 1
MAP9 microtubule-associated protein 9
MN1 meningioma (disrupted in balanced translocation) 1
PBX1 pre-B-cell leukemia homeobox 1
PDZD2 PDZ domain containing 2
PEG3 paternally expressed 3
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SRSF7 serine/arginine-rich splicing factor 7
TMEM158 transmembrane protein 158 (gene/pseudogene)
XIST X inactive specific transcript (non-protein coding)
Funding