BRD-K62810658_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K62810658_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
ASCL1 achaete-scute family bHLH transcription factor 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CPT1A carnitine palmitoyltransferase 1A (liver)
CXCL12 chemokine (C-X-C motif) ligand 12
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
INSR insulin receptor
ISOC1 isochorismatase domain containing 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MAP7 microtubule-associated protein 7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TUSC3 tumor suppressor candidate 3
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
BST2 bone marrow stromal cell antigen 2
C8ORF4 chromosome 8 open reading frame 4
CCL20 chemokine (C-C motif) ligand 20
CCNA1 cyclin A1
CFI complement factor I
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
FXYD2 FXYD domain containing ion transport regulator 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
INPP1 inositol polyphosphate-1-phosphatase
KCTD12 potassium channel tetramerization domain containing 12
LEF1 lymphoid enhancer-binding factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSX1 msh homeobox 1
MT1E metallothionein 1E
MX1 MX dynamin-like GTPase 1
NAV2 neuron navigator 2
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RNF167 ring finger protein 167
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPRY2 sprouty homolog 2 (Drosophila)
SST somatostatin
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM4 tropomyosin 4
UGCG UDP-glucose ceramide glucosyltransferase
XIST X inactive specific transcript (non-protein coding)
Funding