BRD-K62970326_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K62970326_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARG2 arginase 2
ATF3 activating transcription factor 3
CAPG capping protein (actin filament), gelsolin-like
CAST calpastatin
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHIC2 cysteine-rich hydrophobic domain 2
COCH cochlin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EXT1 exostosin glycosyltransferase 1
FBN2 fibrillin 2
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
IGL immunoglobulin lambda locus
IGLL1 immunoglobulin lambda-like polypeptide 1
IL32 interleukin 32
JUN jun proto-oncogene
JUND jun D proto-oncogene
KRT15 keratin 15, type I
MT1E metallothionein 1E
MYC v-myc avian myelocytomatosis viral oncogene homolog
NUPR1 nuclear protein, transcriptional regulator, 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PDLIM5 PDZ and LIM domain 5
PLK1 polo-like kinase 1
PMM2 phosphomannomutase 2
RHOB ras homolog family member B
RNASE4 ribonuclease, RNase A family, 4
RPS5 ribosomal protein S5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOD2 superoxide dismutase 2, mitochondrial
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STC1 stanniocalcin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TSPAN13 tetraspanin 13
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ANPEP alanyl (membrane) aminopeptidase
BHLHE41 basic helix-loop-helix family, member e41
CCL8 chemokine (C-C motif) ligand 8
CCNG1 cyclin G1
CH25H cholesterol 25-hydroxylase
CHL1 cell adhesion molecule L1-like
CLIC5 chloride intracellular channel 5
COX7B cytochrome c oxidase subunit VIIb
CTSH cathepsin H
DDIT4 DNA-damage-inducible transcript 4
FGFR1 fibroblast growth factor receptor 1
GREM1 gremlin 1, DAN family BMP antagonist
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KDM5D lysine (K)-specific demethylase 5D
KNG1 kininogen 1
MARCKSL1 MARCKS-like 1
MME membrane metallo-endopeptidase
MX2 MX dynamin-like GTPase 2
PODXL podocalyxin-like
PXMP2 peroxisomal membrane protein 2, 22kDa
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SCARB2 scavenger receptor class B, member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRGN serglycin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFRC transferrin receptor
THBS1 thrombospondin 1
TPBG trophoblast glycoprotein
TXLNA taxilin alpha