BRD-K63068307_ZSTK-474_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

235 genes differentially expressed following the BRD-K63068307_ZSTK-474_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
AIM1 absent in melanoma 1
AMOTL2 angiomotin like 2
ANGPTL2 angiopoietin-like 2
ANKRD36B ankyrin repeat domain 36B
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP9A ATPase, class II, type 9A
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
C2CD2 C2 calcium-dependent domain containing 2
CCNG2 cyclin G2
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK14 cyclin-dependent kinase 14
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CLIP3 CAP-GLY domain containing linker protein 3
COL10A1 collagen, type X, alpha 1
COL5A2 collagen, type V, alpha 2
CREBL2 cAMP responsive element binding protein-like 2
CTSK cathepsin K
CXCR4 chemokine (C-X-C motif) receptor 4
CYTH1 cytohesin 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
ETHE1 ethylmalonic encephalopathy 1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
F2R coagulation factor II (thrombin) receptor
FABP4 fatty acid binding protein 4, adipocyte
FAP fibroblast activation protein, alpha
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOXG1 forkhead box G1
FOXO4 forkhead box O4
FPR1 formyl peptide receptor 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GSDMB gasdermin B
H1FX H1 histone family, member X
H3F3B H3 histone, family 3B (H3.3B)
HAUS4 HAUS augmin-like complex, subunit 4
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HMGB3 high mobility group box 3
HNMT histamine N-methyltransferase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
HTRA1 HtrA serine peptidase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JOSD1 Josephin domain containing 1
JUP junction plakoglobin
KIAA0355 KIAA0355
KLF11 Kruppel-like factor 11
KLF2 Kruppel-like factor 2
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LIMCH1 LIM and calponin homology domains 1
LOC100272216 uncharacterized LOC100272216
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MMP1 matrix metallopeptidase 1
MMP11 matrix metallopeptidase 11
MMP2 matrix metallopeptidase 2
MMRN1 multimerin 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L1 NEDD4 binding protein 2-like 1
NARFL nuclear prelamin A recognition factor-like
OSBPL1A oxysterol binding protein-like 1A
PDE4B phosphodiesterase 4B, cAMP-specific
PGLS 6-phosphogluconolactonase
PLAU plasminogen activator, urokinase
PLSCR4 phospholipid scramblase 4
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PTPRE protein tyrosine phosphatase, receptor type, E
PXDN peroxidasin
RALBP1 ralA binding protein 1
RB1CC1 RB1-inducible coiled-coil 1
RHOB ras homolog family member B
RNF130 ring finger protein 130
RTN2 reticulon 2
SFRP4 secreted frizzled-related protein 4
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35E2B solute carrier family 35, member E2B
SLC38A2 solute carrier family 38, member 2
SOX4 SRY (sex determining region Y)-box 4
SPG11 spastic paraplegia 11 (autosomal recessive)
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
ST18 suppression of tumorigenicity 18, zinc finger
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNE2 spectrin repeat containing, nuclear envelope 2
TCEA2 transcription elongation factor A (SII), 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGIF1 TGFB-induced factor homeobox 1
TMSB15A thymosin beta 15a
TMSB15B thymosin beta 15B
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TSPAN5 tetraspanin 5
VAT1 vesicle amine transport 1
VCAN versican
WDR19 WD repeat domain 19
YPEL1 yippee-like 1 (Drosophila)
ZNF22 zinc finger protein 22
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADGRG1 adhesion G protein-coupled receptor G1
AK4 adenylate kinase 4
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAG2 BCL2-associated athanogene 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1ORF116 chromosome 1 open reading frame 116
CA12 carbonic anhydrase XII
CAB39 calcium binding protein 39
CALU calumenin
CCDC86 coiled-coil domain containing 86
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD58 CD58 molecule
CLDN18 claudin 18
CLU clusterin
CTSC cathepsin C
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
EGF epidermal growth factor
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM162A family with sequence similarity 162, member A
FAM98A family with sequence similarity 98, member A
FKBP10 FK506 binding protein 10, 65 kDa
FKBP11 FK506 binding protein 11, 19 kDa
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GLRX2 glutaredoxin 2
GPC3 glypican 3
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GYG1 glycogenin 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HK1 hexokinase 1
HK2 hexokinase 2
HOMER2 homer scaffolding protein 2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPH1 heat shock 105kDa/110kDa protein 1
IARS isoleucyl-tRNA synthetase
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
IRF4 interferon regulatory factor 4
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MARS methionyl-tRNA synthetase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MINA MYC induced nuclear antigen
MOK MOK protein kinase
NPY neuropeptide Y
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAX8 paired box 8
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDIA3 protein disulfide isomerase family A, member 3
PGC progastricsin (pepsinogen C)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PITRM1 pitrilysin metallopeptidase 1
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX6 peroxiredoxin 6
PSAT1 phosphoserine aminotransferase 1
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QPRT quinolinate phosphoribosyltransferase
RAD23B RAD23 homolog B (S. cerevisiae)
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCARB1 scavenger receptor class B, member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SORD sorbitol dehydrogenase
SPAG4 sperm associated antigen 4
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
SUB1 SUB1 homolog (S. cerevisiae)
TARS threonyl-tRNA synthetase
TFRC transferrin receptor
TRIM16 tripartite motif containing 16
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VDAC1 voltage-dependent anion channel 1
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
Funding