BRD-K63068307_ZSTK-474_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K63068307_ZSTK-474_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM28 ADAM metallopeptidase domain 28
ADI1 acireductone dioxygenase 1
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMOTL2 angiomotin like 2
ASS1 argininosuccinate synthase 1
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBS1 Bardet-Biedl syndrome 1
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
BRD8 bromodomain containing 8
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CFI complement factor I
CHMP1B charged multivesicular body protein 1B
CLDN4 claudin 4
CPVL carboxypeptidase, vitellogenic-like
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DEPTOR DEP domain containing MTOR-interacting protein
DOCK9 dedicator of cytokinesis 9
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FA2H fatty acid 2-hydroxylase
FAM198B family with sequence similarity 198, member B
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FN1 fibronectin 1
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GBP2 guanylate binding protein 2, interferon-inducible
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GRAMD3 GRAM domain containing 3
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
GSTM2 glutathione S-transferase mu 2 (muscle)
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPG2 heparan sulfate proteoglycan 2
IFI27 interferon, alpha-inducible protein 27
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LAMB2 laminin, beta 2 (laminin S)
LGALS4 lectin, galactoside-binding, soluble, 4
LGALS8 lectin, galactoside-binding, soluble, 8
LXN latexin
MET MET proto-oncogene, receptor tyrosine kinase
MXRA5 matrix-remodelling associated 5
NEK9 NIMA-related kinase 9
NET1 neuroepithelial cell transforming 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM5 PDZ and LIM domain 5
PEX11A peroxisomal biogenesis factor 11 alpha
PGAP3 post-GPI attachment to proteins 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRSS23 protease, serine, 23
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RGS5 regulator of G-protein signaling 5
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SPATA20 spermatogenesis associated 20
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STON1 stonin 1
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TRIB1 tribbles pseudokinase 1
TSPAN1 tetraspanin 1
TSPAN31 tetraspanin 31
TST thiosulfate sulfurtransferase (rhodanese)
TXNIP thioredoxin interacting protein
USP6NL USP6 N-terminal like
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF83 zinc finger protein 83
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADM adrenomedullin
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNE2 cyclin E2
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CENPU centromere protein U
COL6A2 collagen, type VI, alpha 2
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
FABP7 fatty acid binding protein 7, brain
FASN fatty acid synthase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KLHL7 kelch-like family member 7
KRT5 keratin 5, type II
LMNB1 lamin B1
LTF lactotransferrin
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1M metallothionein 1M
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NXT1 nuclear transport factor 2-like export factor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCOLCE2 procollagen C-endopeptidase enhancer 2
PFKP phosphofructokinase, platelet
PI3 peptidase inhibitor 3, skin-derived
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POPDC3 popeye domain containing 3
QDPR quinoid dihydropteridine reductase
RANBP1 RAN binding protein 1
S100A7 S100 calcium binding protein A7
SFN stratifin
SPC25 SPC25, NDC80 kinetochore complex component
TFRC transferrin receptor
THAP11 THAP domain containing 11
TNC tenascin C
TPM4 tropomyosin 4
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Funding