BRD-K63150726_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-K63150726_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CYB561 cytochrome b561
DSE dermatan sulfate epimerase
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FKBP14 FK506 binding protein 14, 22 kDa
GFPT1 glutamine--fructose-6-phosphate transaminase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IFITM3 interferon induced transmembrane protein 3
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
LRRC59 leucine rich repeat containing 59
MID1 midline 1
MX1 MX dynamin-like GTPase 1
NUCB2 nucleobindin 2
P4HB prolyl 4-hydroxylase, beta polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PDLIM5 PDZ and LIM domain 5
PGM3 phosphoglucomutase 3
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRSS3 protease, serine, 3
PXDN peroxidasin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SEC24D SEC24 family member D
SEC63 SEC63 homolog (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SRPR signal recognition particle receptor (docking protein)
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM258 transmembrane protein 258
UFM1 ubiquitin-fold modifier 1
WFS1 Wolfram syndrome 1 (wolframin)

decreased expression

Symbol Name
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA2 carbonic anhydrase II
FAIM Fas apoptotic inhibitory molecule
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
HOXB2 homeobox B2
KRT17 keratin 17, type I
LAGE3 L antigen family, member 3
LUM lumican
MFSD10 major facilitator superfamily domain containing 10
MMP3 matrix metallopeptidase 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
RNF167 ring finger protein 167
SCG5 secretogranin V
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SPRED2 sprouty-related, EVH1 domain containing 2
STX1A syntaxin 1A (brain)
TBC1D31 TBC1 domain family, member 31
TM4SF1 transmembrane 4 L six family member 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZIC1 Zic family member 1
Funding