BRD-K63675182_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

42 genes differentially expressed following the BRD-K63675182_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
F13A1 coagulation factor XIII, A1 polypeptide
FADS1 fatty acid desaturase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
LDLR low density lipoprotein receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSMO1 methylsterol monooxygenase 1
MYO6 myosin VI
NSDHL NAD(P) dependent steroid dehydrogenase-like
OAT ornithine aminotransferase
POLR1D polymerase (RNA) I polypeptide D, 16kDa
RNASE6 ribonuclease, RNase A family, k6
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERINC5 serine incorporator 5
SQLE squalene epoxidase
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D4 TBC1 domain family, member 4
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
CA12 carbonic anhydrase XII
CDK6 cyclin-dependent kinase 6
DUSP2 dual specificity phosphatase 2
EIF5 eukaryotic translation initiation factor 5
GMDS GDP-mannose 4,6-dehydratase
HOXC10 homeobox C10
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
MYRF myelin regulatory factor
RGS2 regulator of G-protein signaling 2
SYT1 synaptotagmin I
TFF1 trefoil factor 1
Funding