BRD-K63923597_barasertib_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K63923597_barasertib_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANK2 ankyrin 2, neuronal
ARG2 arginase 2
ASRGL1 asparaginase like 1
C2CD2 C2 calcium-dependent domain containing 2
CALB1 calbindin 1, 28kDa
CD40 CD40 molecule, TNF receptor superfamily member 5
CHN2 chimerin 2
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRYAB crystallin, alpha B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FOS FBJ murine osteosarcoma viral oncogene homolog
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLIPR1 GLI pathogenesis-related 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM5D lysine (K)-specific demethylase 5D
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTB lymphotoxin beta (TNF superfamily, member 3)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MDK midkine (neurite growth-promoting factor 2)
MME membrane metallo-endopeptidase
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NTS neurotensin
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
RPS4Y1 ribosomal protein S4, Y-linked 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SH3YL1 SH3 and SYLF domain containing 1
SNAP25 synaptosomal-associated protein, 25kDa
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SST somatostatin
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
AQP9 aquaporin 9
CALR calreticulin
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCL8 chemokine (C-C motif) ligand 8
COL4A5 collagen, type IV, alpha 5
COL5A1 collagen, type V, alpha 1
CSTA cystatin A (stefin A)
ECM1 extracellular matrix protein 1
EREG epiregulin
H1F0 H1 histone family, member 0
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
MAGEA3 melanoma antigen family A3
MRPS2 mitochondrial ribosomal protein S2
S100A12 S100 calcium binding protein A12
SMC1A structural maintenance of chromosomes 1A
SNAI2 snail family zinc finger 2
TDO2 tryptophan 2,3-dioxygenase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TUBB4B tubulin, beta 4B class IVb
VCAN versican
XIST X inactive specific transcript (non-protein coding)
Funding