BRD-K64052750_gefitinib_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K64052750_gefitinib_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASS1 argininosuccinate synthase 1
B3GNT1
BCHE butyrylcholinesterase
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG1 cyclin G1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CES1 carboxylesterase 1
CLGN calmegin
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CSRP2 cysteine and glycine-rich protein 2
DEFB1 defensin, beta 1
FKBP5 FK506 binding protein 5
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFNGR1 interferon gamma receptor 1
IQGAP2 IQ motif containing GTPase activating protein 2
LOX lysyl oxidase
MAN1A1 mannosidase, alpha, class 1A, member 1
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MMP10 matrix metallopeptidase 10
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIR pirin (iron-binding nuclear protein)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELN reelin
RGS1 regulator of G-protein signaling 1
RPS27L ribosomal protein S27-like
SCARB2 scavenger receptor class B, member 2
SEPP1 selenoprotein P, plasma, 1
SEPW1 selenoprotein W, 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM106C transmembrane protein 106C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TRIP6 thyroid hormone receptor interactor 6
TSC22D3 TSC22 domain family, member 3
ZIC1 Zic family member 1

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
C1ORF116 chromosome 1 open reading frame 116
CAPRIN2 caprin family member 2
CBFB core-binding factor, beta subunit
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDCP1 CUB domain containing protein 1
CREB1 cAMP responsive element binding protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENOPH1 enolase-phosphatase 1
EPHA2 EPH receptor A2
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FST follistatin
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
IER2 immediate early response 2
IER3 immediate early response 3
IL1B interleukin 1, beta
JAG1 jagged 1
JUN jun proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MAT2A methionine adenosyltransferase II, alpha
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NT5E 5'-nucleotidase, ecto (CD73)
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
S100A11 S100 calcium binding protein A11
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TRIB2 tribbles pseudokinase 2
UGCG UDP-glucose ceramide glucosyltransferase
Funding