BRD-K64517075_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K64517075_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CEP57 centrosomal protein 57kDa
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
DENND5A DENN/MADD domain containing 5A
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO3 forkhead box O3
H1F0 H1 histone family, member 0
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSLN mesothelin
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PHGDH phosphoglycerate dehydrogenase
PSPH phosphoserine phosphatase
RPL37A ribosomal protein L37a
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC4 syndecan 4
SFRP1 secreted frizzled-related protein 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TGIF1 TGFB-induced factor homeobox 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
C1QB complement component 1, q subcomponent, B chain
CANT1 calcium activated nucleotidase 1
CCDC86 coiled-coil domain containing 86
CLDN18 claudin 18
FABP5 fatty acid binding protein 5 (psoriasis-associated)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
PDLIM1 PDZ and LIM domain 1
S100A9 S100 calcium binding protein A9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF7 serine/arginine-rich splicing factor 7
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TUBB tubulin, beta class I
WFS1 Wolfram syndrome 1 (wolframin)
Funding