BRD-K64606589_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

285 genes differentially expressed following the BRD-K64606589_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AACS acetoacetyl-CoA synthetase
ABHD3 abhydrolase domain containing 3
ACAD8 acyl-CoA dehydrogenase family, member 8
ACOT7 acyl-CoA thioesterase 7
ACSL3 acyl-CoA synthetase long-chain family member 3
ALAS1 5'-aminolevulinate synthase 1
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARHGAP32 Rho GTPase activating protein 32
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
ATG2A autophagy related 2A
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CCNG2 cyclin G2
CD47 CD47 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIB1 calcium and integrin binding 1 (calmyrin)
CKB creatine kinase, brain
CLDN10 claudin 10
COG5 component of oligomeric golgi complex 5
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CPD carboxypeptidase D
CSRP1 cysteine and glycine-rich protein 1
CTR9 CTR9, Paf1/RNA polymerase II complex component
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
DBP D site of albumin promoter (albumin D-box) binding protein
DCTN3 dynactin 3 (p22)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EFHD1 EF-hand domain family, member D1
EFNB2 ephrin-B2
FAM117A family with sequence similarity 117, member A
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
G6PD glucose-6-phosphate dehydrogenase
GLA galactosidase, alpha
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLGA7 golgin A7
GPN3 GPN-loop GTPase 3
GPR137B G protein-coupled receptor 137B
GSN gelsolin
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HN1 hematological and neurological expressed 1
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IQGAP1 IQ motif containing GTPase activating protein 1
IRF7 interferon regulatory factor 7
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLHL21 kelch-like family member 21
KRT7 keratin 7, type II
LBH limb bud and heart development
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPT microtubule-associated protein tau
MAST3 microtubule associated serine/threonine kinase 3
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLF1 myeloid leukemia factor 1
MLXIP MLX interacting protein
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
MX1 MX dynamin-like GTPase 1
NCOA3 nuclear receptor coactivator 3
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEU1 sialidase 1 (lysosomal sialidase)
NLRP2 NLR family, pyrin domain containing 2
NME5 NME/NM23 family member 5
NOSIP nitric oxide synthase interacting protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAT ornithine aminotransferase
OPTN optineurin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PER3 period circadian clock 3
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PNP purine nucleoside phosphorylase
POLB polymerase (DNA directed), beta
PPARD peroxisome proliferator-activated receptor delta
PRKCD protein kinase C, delta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PURA purine-rich element binding protein A
RAD9A RAD9 homolog A (S. pombe)
RGS10 regulator of G-protein signaling 10
RIMS3 regulating synaptic membrane exocytosis 3
ROGDI rogdi homolog (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGD Ras-related GTP binding D
RTN3 reticulon 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCPEP1 serine carboxypeptidase 1
SEC63 SEC63 homolog (S. cerevisiae)
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIK1 salt-inducible kinase 1
SKP1 S-phase kinase-associated protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC46A3 solute carrier family 46, member 3
SPAG9 sperm associated antigen 9
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
SYNGR2 synaptogyrin 2
TACSTD2 tumor-associated calcium signal transducer 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM110 transmembrane protein 110
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDR47 WD repeat domain 47
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
AKAP8 A kinase (PRKA) anchor protein 8
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA4 annexin A4
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
ATXN10 ataxin 10
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
C1R complement component 1, r subcomponent
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COMT catechol-O-methyltransferase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DRAM1 DNA-damage regulated autophagy modulator 1
EIF5A eukaryotic translation initiation factor 5A
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
F5 coagulation factor V (proaccelerin, labile factor)
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FXN frataxin
GABPB1 GA binding protein transcription factor, beta subunit 1
GAS2 growth arrest-specific 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HDDC2 HD domain containing 2
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL7R interleukin 7 receptor
IRAK1 interleukin-1 receptor-associated kinase 1
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KRT13 keratin 13, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMNB1 lamin B1
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
PDIA3 protein disulfide isomerase family A, member 3
PGC progastricsin (pepsinogen C)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PRDX4 peroxiredoxin 4
PRMT1 protein arginine methyltransferase 1
PRR7 proline rich 7 (synaptic)
PSCA prostate stem cell antigen
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTX3 pentraxin 3, long
RAD23B RAD23 homolog B (S. cerevisiae)
RBMX RNA binding motif protein, X-linked
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELN reelin
RSL1D1 ribosomal L1 domain containing 1
S100A10 S100 calcium binding protein A10
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRSF5 serine/arginine-rich splicing factor 5
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TARP TCR gamma alternate reading frame protein
TCERG1 transcription elongation regulator 1
TF transferrin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNC1 troponin C type 1 (slow)
TSC22D1 TSC22 domain family, member 1
TSKU tsukushi, small leucine rich proteoglycan
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP22 ubiquitin specific peptidase 22
VCAN versican
VTN vitronectin
WEE1 WEE1 G2 checkpoint kinase
YBX3 Y box binding protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYND8 zinc finger, MYND-type containing 8
Funding