BRD-K64634304_Retinoic acid_HCT116_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K64634304_Retinoic acid_HCT116_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF62 chromosome 6 open reading frame 62
CCK cholecystokinin
CD52 CD52 molecule
CD58 CD58 molecule
CDC42 cell division cycle 42
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC3B C-type lectin domain family 3, member B
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
COMT catechol-O-methyltransferase
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EMC3 ER membrane protein complex subunit 3
F5 coagulation factor V (proaccelerin, labile factor)
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GCH1 GTP cyclohydrolase 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IFNGR1 interferon gamma receptor 1
IL7R interleukin 7 receptor
KLHL21 kelch-like family member 21
KYNU kynureninase
LGALS8 lectin, galactoside-binding, soluble, 8
LRIF1 ligand dependent nuclear receptor interacting factor 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP7 matrix metallopeptidase 7
MSX1 msh homeobox 1
MYBPC1 myosin binding protein C, slow type
NME5 NME/NM23 family member 5
NNMT nicotinamide N-methyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PIR pirin (iron-binding nuclear protein)
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTN pleiotrophin
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SH3BGR SH3 domain binding glutamate-rich protein
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQSTM1 sequestosome 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS4 thrombospondin 4
TMEM47 transmembrane protein 47
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TXNRD1 thioredoxin reductase 1
VCAM1 vascular cell adhesion molecule 1
WISP2 WNT1 inducible signaling pathway protein 2

decreased expression

Symbol Name
AIM2 absent in melanoma 2
ANXA3 annexin A3
CADM1 cell adhesion molecule 1
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL6A1 collagen, type VI, alpha 1
CPM carboxypeptidase M
CTSH cathepsin H
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
GRB7 growth factor receptor-bound protein 7
HMGA2 high mobility group AT-hook 2
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
INHBB inhibin, beta B
ITGA6 integrin, alpha 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLK11 kallikrein-related peptidase 11
LAMC2 laminin, gamma 2
MSN moesin
MSRA methionine sulfoxide reductase A
NLGN4X neuroligin 4, X-linked
NT5DC2 5'-nucleotidase domain containing 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PER1 period circadian clock 1
PGAP3 post-GPI attachment to proteins 3
POU2AF1 POU class 2 associating factor 1
PXDN peroxidasin
RGS4 regulator of G-protein signaling 4
SCRN1 secernin 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TXNIP thioredoxin interacting protein
USP22 ubiquitin specific peptidase 22
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2
Funding