BRD-K64634304_Retinoic acid_PL21_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K64634304_Retinoic acid_PL21_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AIF1 allograft inflammatory factor 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATP10A ATPase, class V, type 10A
ATP9A ATPase, class II, type 9A
BET1 Bet1 golgi vesicular membrane trafficking protein
BTG3 BTG family, member 3
C5AR1 complement component 5a receptor 1
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNA1 cyclin A1
CCR1 chemokine (C-C motif) receptor 1
CD163 CD163 molecule
CES1 carboxylesterase 1
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
CLIC4 chloride intracellular channel 4
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL5 chemokine (C-X-C motif) ligand 5
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DUSP6 dual specificity phosphatase 6
FABP4 fatty acid binding protein 4, adipocyte
FN1 fibronectin 1
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HOXD1 homeobox D1
IFI44 interferon-induced protein 44
IFITM1 interferon induced transmembrane protein 1
IL13RA1 interleukin 13 receptor, alpha 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KYNU kynureninase
LOC100505650 uncharacterized LOC100505650
LSP1 lymphocyte-specific protein 1
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
NOTCH1 notch 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PON3 paraoxonase 3
PROM1 prominin 1
RAB31 RAB31, member RAS oncogene family
RBKS ribokinase
RGS10 regulator of G-protein signaling 10
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SLA Src-like-adaptor
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS1 sorbin and SH3 domain containing 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TREM1 triggering receptor expressed on myeloid cells 1
TUBA4A tubulin, alpha 4a
VCAN versican
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
AEBP1 AE binding protein 1
AZU1 azurocidin 1
BCL2 B-cell CLL/lymphoma 2
BMP2 bone morphogenetic protein 2
CAST calpastatin
CD320 CD320 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CLEC11A C-type lectin domain family 11, member A
CSRP2 cysteine and glycine-rich protein 2
EIF3B eukaryotic translation initiation factor 3, subunit B
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM3C family with sequence similarity 3, member C
FKBP14 FK506 binding protein 14, 22 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
IFRD2 interferon-related developmental regulator 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MGP matrix Gla protein
MRPL12 mitochondrial ribosomal protein L12
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIB nuclear factor I/B
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
ODC1 ornithine decarboxylase 1
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRMT1 protein arginine methyltransferase 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PUS7 pseudouridylate synthase 7 (putative)
RALBP1 ralA binding protein 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
SEH1L SEH1-like (S. cerevisiae)
SELE selectin E
SMYD2 SET and MYND domain containing 2
TCF3 transcription factor 3
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
WDR3 WD repeat domain 3
Funding