BRD-K64642496_-666_A673_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K64642496_-666_A673_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
ASNS asparagine synthetase (glutamine-hydrolyzing)
C3 complement component 3
C7 complement component 7
CANX calnexin
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CLU clusterin
COLEC11 collectin sub-family member 11
COPA coatomer protein complex, subunit alpha
CTTN cortactin
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
EPRS glutamyl-prolyl-tRNA synthetase
EREG epiregulin
EZR ezrin
FAM198B family with sequence similarity 198, member B
FKBP5 FK506 binding protein 5
FOXC1 forkhead box C1
G6PD glucose-6-phosphate dehydrogenase
GNS glucosamine (N-acetyl)-6-sulfatase
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER3 homer scaffolding protein 3
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HYOU1 hypoxia up-regulated 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
KRT19 keratin 19, type I
LEPR leptin receptor
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
LUM lumican
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFSD10 major facilitator superfamily domain containing 10
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPY1R neuropeptide Y receptor Y1
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL1A oxysterol binding protein-like 1A
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA6 protein disulfide isomerase family A, member 6
PEG10 paternally expressed 10
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PXDN peroxidasin
RELN reelin
RND3 Rho family GTPase 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SNAP23 synaptosomal-associated protein, 23kDa
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STC2 stanniocalcin 2
STX16 syntaxin 16
TACSTD2 tumor-associated calcium signal transducer 2
TLR4 toll-like receptor 4
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TTN titin
TXNIP thioredoxin interacting protein
WSB1 WD repeat and SOCS box containing 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADGRL2 adhesion G protein-coupled receptor L2
BCHE butyrylcholinesterase
BPHL biphenyl hydrolase-like (serine hydrolase)
C11ORF95 chromosome 11 open reading frame 95
C1ORF106 chromosome 1 open reading frame 106
CCNF cyclin F
CD200 CD200 molecule
CD44 CD44 molecule (Indian blood group)
CD8A CD8a molecule
CD93 CD93 molecule
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHERP calcium homeostasis endoplasmic reticulum protein
CIAPIN1 cytokine induced apoptosis inhibitor 1
EFCAB14 EF-hand calcium binding domain 14
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EPHB3 EPH receptor B3
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXO1 forkhead box O1
GAS1 growth arrest-specific 1
GPX2 glutathione peroxidase 2
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL7R interleukin 7 receptor
ITM2A integral membrane protein 2A
JMJD6 jumonji domain containing 6
LMNB2 lamin B2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MAP2K3 mitogen-activated protein kinase kinase 3
MEIS2 Meis homeobox 2
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MSN moesin
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NAV2 neuron navigator 2
NID1 nidogen 1
NOTCH3 notch 3
NUP62 nucleoporin 62kDa
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDE4B phosphodiesterase 4B, cAMP-specific
PIP prolactin-induced protein
PRKCA protein kinase C, alpha
PSRC1 proline/serine-rich coiled-coil 1
RAB15 RAB15, member RAS oncogene family
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RGS1 regulator of G-protein signaling 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF144A ring finger protein 144A
SDC1 syndecan 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSH1 slingshot protein phosphatase 1
TMEM2 transmembrane protein 2
TMEM255A transmembrane protein 255A
TUBB2A tubulin, beta 2A class IIa
UBE3C ubiquitin protein ligase E3C
VGLL4 vestigial-like family member 4
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZMIZ1 zinc finger, MIZ-type containing 1
Funding