BRD-K64642496_-666_PC3_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

339 genes differentially expressed following the BRD-K64642496_-666_PC3_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADGRG1 adhesion G protein-coupled receptor G1
ALAS1 5'-aminolevulinate synthase 1
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCDC85B coiled-coil domain containing 85B
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK14 cyclin-dependent kinase 14
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CES2 carboxylesterase 2
CHGB chromogranin B
CIRBP cold inducible RNA binding protein
CLCA4 chloride channel accessory 4
CLDN3 claudin 3
CLDN7 claudin 7
CPE carboxypeptidase E
CTBP2 C-terminal binding protein 2
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDN3 endothelin 3
EGFR epidermal growth factor receptor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FKBP11 FK506 binding protein 11, 19 kDa
FTH1 ferritin, heavy polypeptide 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GALC galactosylceramidase
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOLGA8H golgin A8 family, member H
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
GUSBP11 glucuronidase, beta pseudogene 11
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IFI27 interferon, alpha-inducible protein 27
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IGF2R insulin-like growth factor 2 receptor
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KDM7A lysine (K)-specific demethylase 7A
KRT23 keratin 23, type I
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
LGALS4 lectin, galactoside-binding, soluble, 4
LIMCH1 LIM and calponin homology domains 1
LRP10 low density lipoprotein receptor-related protein 10
LRRC8D leucine rich repeat containing 8 family, member D
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED2 melanoma antigen family D2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP1 matrix metallopeptidase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
NFIL3 nuclear factor, interleukin 3 regulated
NIT1 nitrilase 1
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPRG protein tyrosine phosphatase, receptor type, G
RAP1GAP RAP1 GTPase activating protein
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
REG1A regenerating islet-derived 1 alpha
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RNF19B ring finger protein 19B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRBP1 ribosome binding protein 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGCE sarcoglycan, epsilon
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRGN serglycin
SST somatostatin
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TCEA1 transcription elongation factor A (SII), 1
TFPI2 tissue factor pathway inhibitor 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TRIB3 tribbles pseudokinase 3
TSPAN31 tetraspanin 31
TST thiosulfate sulfurtransferase (rhodanese)
UPP1 uridine phosphorylase 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACOT7 acyl-CoA thioesterase 7
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AK4 adenylate kinase 4
ANXA5 annexin A5
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
B3GNT1
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND1 cyclin D1
CCND3 cyclin D3
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CLEC11A C-type lectin domain family 11, member A
CLEC2B C-type lectin domain family 2, member B
CRIP1 cysteine-rich protein 1 (intestinal)
CRYZ crystallin, zeta (quinone reductase)
CYFIP1 cytoplasmic FMR1 interacting protein 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHFR dihydrofolate reductase
DICER1 dicer 1, ribonuclease type III
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNM1 dynamin 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGR3 early growth response 3
ENO1 enolase 1, (alpha)
ERAP2 endoplasmic reticulum aminopeptidase 2
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAL galanin/GMAP prepropeptide
GAS2L1 growth arrest-specific 2 like 1
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLUL glutamate-ammonia ligase
HADH hydroxyacyl-CoA dehydrogenase
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA10 homeobox A10
HOXC6 homeobox C6
HP haptoglobin
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KPNB1 karyopherin (importin) beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MLANA melan-A
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MREG melanoregulin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
OLFM1 olfactomedin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PMEL premelanosome protein
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRKCH protein kinase C, eta
PRMT1 protein arginine methyltransferase 1
PTDSS1 phosphatidylserine synthase 1
PTMA prothymosin, alpha
PURA purine-rich element binding protein A
RAD51 RAD51 recombinase
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
SEPT8 septin 8
SFPQ splicing factor proline/glutamine-rich
SHCBP1 SHC SH2-domain binding protein 1
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPC25 SPC25, NDC80 kinetochore complex component
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYNM synemin, intermediate filament protein
TACC3 transforming, acidic coiled-coil containing protein 3
TAGLN2 transgelin 2
TFDP1 transcription factor Dp-1
TK1 thymidine kinase 1, soluble
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UNG uracil-DNA glycosylase
VRK1 vaccinia related kinase 1
ZBTB18 zinc finger and BTB domain containing 18
ZWINT ZW10 interacting kinetochore protein
Funding