BRD-K64642496_-666_SKMEL28_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

192 genes differentially expressed following the BRD-K64642496_-666_SKMEL28_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACPP acid phosphatase, prostate
ADAM10 ADAM metallopeptidase domain 10
AHSP alpha hemoglobin stabilizing protein
AQP1 aquaporin 1 (Colton blood group)
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BMP4 bone morphogenetic protein 4
C3 complement component 3
CA1 carbonic anhydrase I
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAST calpastatin
CCND2 cyclin D2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CFD complement factor D (adipsin)
CLCA1 chloride channel accessory 1
CLCA4 chloride channel accessory 4
CPE carboxypeptidase E
CTNND1 catenin (cadherin-associated protein), delta 1
CXADR coxsackie virus and adenovirus receptor
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
EHF ets homologous factor
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM129A family with sequence similarity 129, member A
FBXL5 F-box and leucine-rich repeat protein 5
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FILIP1L filamin A interacting protein 1-like
FRY furry homolog (Drosophila)
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL1R1 interleukin 1 receptor, type I
INA internexin neuronal intermediate filament protein, alpha
IRF6 interferon regulatory factor 6
ISYNA1 inositol-3-phosphate synthase 1
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
LTBP1 latent transforming growth factor beta binding protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MPZL2 myelin protein zero-like 2
MSLN mesothelin
MSMB microseminoprotein, beta-
MTMR11 myotubularin related protein 11
MXRA5 matrix-remodelling associated 5
NIT1 nitrilase 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5DC2 5'-nucleotidase domain containing 2
NUAK1 NUAK family, SNF1-like kinase, 1
OLFM4 olfactomedin 4
PAPD7 PAP associated domain containing 7
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PEA15 phosphoprotein enriched in astrocytes 15
PLN phospholamban
POSTN periostin, osteoblast specific factor
PPOX protoporphyrinogen oxidase
PRSS16 protease, serine, 16 (thymus)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRF protein tyrosine phosphatase, receptor type, F
RAB21 RAB21, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
RTN2 reticulon 2
SELENBP1 selenium binding protein 1
SERINC5 serine incorporator 5
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK38L serine/threonine kinase 38 like
STON1 stonin 1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TBX3 T-box 3
TCEAL2 transcription elongation factor A (SII)-like 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TMEM35 transmembrane protein 35
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TSPAN12 tetraspanin 12
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VSNL1 visinin-like 1
XIST X inactive specific transcript (non-protein coding)
ZHX2 zinc fingers and homeoboxes 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
AKAP7 A kinase (PRKA) anchor protein 7
APOD apolipoprotein D
ARFIP2 ADP-ribosylation factor interacting protein 2
BIN1 bridging integrator 1
BST2 bone marrow stromal cell antigen 2
CBR3 carbonyl reductase 3
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
EBP emopamil binding protein (sterol isomerase)
ECI2 enoyl-CoA delta isomerase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GAS1 growth arrest-specific 1
GSTP1 glutathione S-transferase pi 1
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KRT10 keratin 10, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAN2B1 mannosidase, alpha, class 2B, member 1
MIA melanoma inhibitory activity
MRPS16 mitochondrial ribosomal protein S16
MXRA7 matrix-remodelling associated 7
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
NFIB nuclear factor I/B
NPC2 Niemann-Pick disease, type C2
NUP62 nucleoporin 62kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PEBP1 phosphatidylethanolamine binding protein 1
PHB prohibitin
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA1A phospholipase A1 member A
PLIN3 perilipin 3
PLK1 polo-like kinase 1
PRDX4 peroxiredoxin 4
PRMT1 protein arginine methyltransferase 1
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PXMP2 peroxisomal membrane protein 2, 22kDa
QDPR quinoid dihydropteridine reductase
RABAC1 Rab acceptor 1 (prenylated)
RPL36 ribosomal protein L36
RPN2 ribophorin II
RPS11 ribosomal protein S11
RPS26 ribosomal protein S26
RPS27L ribosomal protein S27-like
RUVBL2 RuvB-like AAA ATPase 2
S100B S100 calcium binding protein B
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SNX10 sorting nexin 10
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMED3 transmembrane emp24 protein transport domain containing 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM28 tripartite motif containing 28
TSPAN3 tetraspanin 3
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UBE2S ubiquitin-conjugating enzyme E2S
Funding