BRD-K64642496_-666_VCAP_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-K64642496_-666_VCAP_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
ACAT2 acetyl-CoA acetyltransferase 2
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD99 CD99 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CST3 cystatin C
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
EPRS glutamyl-prolyl-tRNA synthetase
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLUL glutamate-ammonia ligase
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
INHBA inhibin, beta A
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT15 keratin 15, type I
LDLR low density lipoprotein receptor
LINC00341 long intergenic non-protein coding RNA 341
LPIN1 lipin 1
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHGDH phosphoglycerate dehydrogenase
PNRC1 proline-rich nuclear receptor coactivator 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RSL24D1 ribosomal L24 domain containing 1
SARS seryl-tRNA synthetase
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SCRG1 stimulator of chondrogenesis 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SESN1 sestrin 1
SGCE sarcoglycan, epsilon
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
STC2 stanniocalcin 2
SULF1 sulfatase 1
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TFF1 trefoil factor 1
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VCAN versican
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CCNE1 cyclin E1
CCNE2 cyclin E2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLIPR1 GLI pathogenesis-related 1
GTSE1 G-2 and S-phase expressed 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP7 insulin-like growth factor binding protein 7
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
LAPTM5 lysosomal protein transmembrane 5
LDHB lactate dehydrogenase B
MBP myelin basic protein
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MECOM MDS1 and EVI1 complex locus
MSH6 mutS homolog 6
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NOP56 NOP56 ribonucleoprotein
PBK PDZ binding kinase
PCDH7 protocadherin 7
PLS3 plastin 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
RRM2 ribonucleotide reductase M2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SHCBP1 SHC SH2-domain binding protein 1
SLBP stem-loop binding protein
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRRM1 serine/arginine repetitive matrix 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TRIB2 tribbles pseudokinase 2
TUBA4A tubulin, alpha 4a
WBP5 WW domain binding protein 5
ZBTB1 zinc finger and BTB domain containing 1
Funding