BRD-K64800655_PHA-793887_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K64800655_PHA-793887_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACKR3 atypical chemokine receptor 3
AKAP12 A kinase (PRKA) anchor protein 12
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BLCAP bladder cancer associated protein
CCDC92 coiled-coil domain containing 92
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSZ cathepsin Z
DACH1 dachshund family transcription factor 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
E2F2 E2F transcription factor 2
EGR2 early growth response 2
FAM131A family with sequence similarity 131, member A
FAM63A family with sequence similarity 63, member A
FAS Fas cell surface death receptor
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GLIPR1 GLI pathogenesis-related 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HSPA1A heat shock 70kDa protein 1A
ICAM3 intercellular adhesion molecule 3
INPP1 inositol polyphosphate-1-phosphatase
JUNB jun B proto-oncogene
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NR4A2 nuclear receptor subfamily 4, group A, member 2
PGC progastricsin (pepsinogen C)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RBP1 retinol binding protein 1, cellular
RIOK3 RIO kinase 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
SLPI secretory leukocyte peptidase inhibitor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPST2 tyrosylprotein sulfotransferase 2
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CD200 CD200 molecule
CD302 CD302 molecule
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ELANE elastase, neutrophil expressed
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP7 fatty acid binding protein 7, brain
FZD7 frizzled class receptor 7
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LBR lamin B receptor
LMNB2 lamin B2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
NDC80 NDC80 kinetochore complex component
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RRM2 ribonucleotide reductase M2
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
SAP30 Sin3A-associated protein, 30kDa
SCGB1D2 secretoglobin, family 1D, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF3 serine/arginine-rich splicing factor 3
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TCF3 transcription factor 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRMT5 tRNA methyltransferase 5
TTK TTK protein kinase
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TXNDC9 thioredoxin domain containing 9
VCAN versican
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
Funding