BRD-K64800655_PHA-793887_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K64800655_PHA-793887_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACLY ATP citrate lyase
ACTC1 actin, alpha, cardiac muscle 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ASMTL acetylserotonin O-methyltransferase-like
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
CCND2 cyclin D2
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLU clusterin
COG5 component of oligomeric golgi complex 5
CSTA cystatin A (stefin A)
CYFIP1 cytoplasmic FMR1 interacting protein 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DPP4 dipeptidyl-peptidase 4
DUSP10 dual specificity phosphatase 10
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
EID1 EP300 interacting inhibitor of differentiation 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FOLR1 folate receptor 1 (adult)
FUCA1 fucosidase, alpha-L- 1, tissue
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLM1 golgi membrane protein 1
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HSPB8 heat shock 22kDa protein 8
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
KDM5D lysine (K)-specific demethylase 5D
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
LY6D lymphocyte antigen 6 complex, locus D
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
PDZK1IP1 PDZK1 interacting protein 1
PI3 peptidase inhibitor 3, skin-derived
PON2 paraoxonase 2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SAMM50 SAMM50 sorting and assembly machinery component
SELL selectin L
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SPATA20 spermatogenesis associated 20
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASCL1 achaete-scute family bHLH transcription factor 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CCNI cyclin I
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CKAP2 cytoskeleton associated protein 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN7 claudin 7
CXCL12 chemokine (C-X-C motif) ligand 12
DEK DEK proto-oncogene
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ECT2 epithelial cell transforming 2
EPCAM epithelial cell adhesion molecule
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
F11R F11 receptor
FAM64A family with sequence similarity 64, member A
FAP fibroblast activation protein, alpha
FBXO5 F-box protein 5
FOXM1 forkhead box M1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GRP gastrin-releasing peptide
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IFRD2 interferon-related developmental regulator 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
MAPK13 mitogen-activated protein kinase 13
MELK maternal embryonic leucine zipper kinase
METTL7A methyltransferase like 7A
MKI67 marker of proliferation Ki-67
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PBX3 pre-B-cell leukemia homeobox 3
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RCC1 regulator of chromosome condensation 1
RRM2 ribonucleotide reductase M2
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
THBS2 thrombospondin 2
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRMT5 tRNA methyltransferase 5
TROAP trophinin associated protein
TTK TTK protein kinase
TUBB6 tubulin, beta 6 class V
UBE2C ubiquitin-conjugating enzyme E2C
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
Funding