BRD-K64800655_PHA-793887_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

242 genes differentially expressed following the BRD-K64800655_PHA-793887_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AIF1 allograft inflammatory factor 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND1 cyclin D1
CD163 CD163 molecule
CD24 CD24 molecule
COL9A2 collagen, type IX, alpha 2
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CTSA cathepsin A
CTSC cathepsin C
CXADR coxsackie virus and adenovirus receptor
CYB5R1 cytochrome b5 reductase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
DUOX2 dual oxidase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FCGBP Fc fragment of IgG binding protein
GAA glucosidase, alpha; acid
GLS glutaminase
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAV integrin, alpha V
JAG1 jagged 1
LGMN legumain
LPIN1 lipin 1
LXN latexin
MAST2 microtubule associated serine/threonine kinase 2
MSMO1 methylsterol monooxygenase 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PI3 peptidase inhibitor 3, skin-derived
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
RABAC1 Rab acceptor 1 (prenylated)
RBKS ribokinase
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REEP5 receptor accessory protein 5
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SCPEP1 serine carboxypeptidase 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SGCE sarcoglycan, epsilon
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
TES testin LIM domain protein
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53I3 tumor protein p53 inducible protein 3
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
UBXN4 UBX domain protein 4

decreased expression

Symbol Name
AEBP1 AE binding protein 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
CIT citron rho-interacting serine/threonine kinase
COL6A2 collagen, type VI, alpha 2
DAPK1 death-associated protein kinase 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM111A family with sequence similarity 111, member A
FAM129A family with sequence similarity 129, member A
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FGF13 fibroblast growth factor 13
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPNMB glycoprotein (transmembrane) nmb
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HBE1 hemoglobin, epsilon 1
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
HMGB2 high mobility group box 2
HMGN2 high mobility group nucleosomal binding domain 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF20B kinesin family member 20B
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LDHB lactate dehydrogenase B
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LTF lactotransferrin
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MSH6 mutS homolog 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NPY1R neuropeptide Y receptor Y1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSAT1 phosphoserine aminotransferase 1
PSRC1 proline/serine-rich coiled-coil 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RANBP1 RAN binding protein 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMEM47 transmembrane protein 47
TMPO thymopoietin
TMSB15A thymosin beta 15a
TNIK TRAF2 and NCK interacting kinase
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TROAP trophinin associated protein
TTK TTK protein kinase
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WNT5A wingless-type MMTV integration site family, member 5A
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZBTB18 zinc finger and BTB domain containing 18
ZWINT ZW10 interacting kinetochore protein
Funding