BRD-K64800655_PHA-793887_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-K64800655_PHA-793887_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHGB chromogranin B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL4A1 collagen, type IV, alpha 1
COL6A3 collagen, type VI, alpha 3
CSRP1 cysteine and glycine-rich protein 1
CTTN cortactin
CYB5R1 cytochrome b5 reductase 1
DSP desmoplakin
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FLNB filamin B, beta
GJA1 gap junction protein, alpha 1, 43kDa
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HEBP2 heme binding protein 2
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0125 KIAA0125
KRT16 keratin 16, type I
KRT81 keratin 81, type II
LAMP2 lysosomal-associated membrane protein 2
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
NXN nucleoredoxin
OPTN optineurin
OXSR1 oxidative stress responsive 1
PALLD palladin, cytoskeletal associated protein
PEG10 paternally expressed 10
PHF20 PHD finger protein 20
POU2AF1 POU class 2 associating factor 1
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRAME preferentially expressed antigen in melanoma
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC16A6 solute carrier family 16, member 6
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRR3 small proline-rich protein 3
STC2 stanniocalcin 2
STXBP2 syntaxin binding protein 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCEAL4 transcription elongation factor A (SII)-like 4
TCF4 transcription factor 4
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPM2 tropomyosin 2 (beta)
TSPAN13 tetraspanin 13
VCL vinculin

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKB aurora kinase B
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
C11ORF95 chromosome 11 open reading frame 95
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC45 cell division cycle 45
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CRTAP cartilage associated protein
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
ELP5 elongator acetyltransferase complex subunit 5
ETV1 ets variant 1
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA5 homeobox A5
HOXB2 homeobox B2
IGFBP5 insulin-like growth factor binding protein 5
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCL1 myeloid cell leukemia 1
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NBN nibrin
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PARP2 poly (ADP-ribose) polymerase 2
PHGDH phosphoglycerate dehydrogenase
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RACGAP1 Rac GTPase activating protein 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOBTB3 Rho-related BTB domain containing 3
RNF130 ring finger protein 130
RRM2 ribonucleotide reductase M2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLIT2 slit homolog 2 (Drosophila)
SMC1A structural maintenance of chromosomes 1A
SMC4 structural maintenance of chromosomes 4
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TMEM123 transmembrane protein 123
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TRBC1 T cell receptor beta constant 1
TRIB2 tribbles pseudokinase 2
TRMT5 tRNA methyltransferase 5
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
WNT5A wingless-type MMTV integration site family, member 5A
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
Funding