BRD-K64800655_PHA-793887_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K64800655_PHA-793887_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
C6ORF48 chromosome 6 open reading frame 48
CA12 carbonic anhydrase XII
CFB complement factor B
CLIC3 chloride intracellular channel 3
CLU clusterin
DIO2 deiodinase, iodothyronine, type II
DYNLT1 dynein, light chain, Tctex-type 1
EDNRA endothelin receptor type A
EGR1 early growth response 1
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
LEF1 lymphoid enhancer-binding factor 1
MMP11 matrix metallopeptidase 11
MOXD1 monooxygenase, DBH-like 1
NPDC1 neural proliferation, differentiation and control, 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PEG10 paternally expressed 10
PRAME preferentially expressed antigen in melanoma
PRKCQ protein kinase C, theta
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
SDC2 syndecan 2
SEPW1 selenoprotein W, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
STK39 serine threonine kinase 39
TP53I3 tumor protein p53 inducible protein 3
TUBB6 tubulin, beta 6 class V

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIK BCL2-interacting killer (apoptosis-inducing)
CAMP cathelicidin antimicrobial peptide
CCNA2 cyclin A2
CCNF cyclin F
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYBA cytochrome b-245, alpha polypeptide
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM46A family with sequence similarity 46, member A
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GAS1 growth arrest-specific 1
HLF hepatic leukemia factor
HMG20B high mobility group 20B
HOXA5 homeobox A5
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KIF14 kinesin family member 14
KLF11 Kruppel-like factor 11
KLHL2 kelch-like family member 2
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
KYNU kynureninase
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NPTX1 neuronal pentraxin I
NPY neuropeptide Y
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PRNP prion protein
PRUNE prune exopolyphosphatase
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RBM38 RNA binding motif protein 38
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SRSF7 serine/arginine-rich splicing factor 7
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
ZFP36L2 ZFP36 ring finger protein-like 2
Funding