BRD-K64800655_PHA-793887_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-K64800655_PHA-793887_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD10 ankyrin repeat domain 10
AP3D1 adaptor-related protein complex 3, delta 1 subunit
CCND2 cyclin D2
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSE cathepsin E
CXCL11 chemokine (C-X-C motif) ligand 11
DHRS2 dehydrogenase/reductase (SDR family) member 2
EMP1 epithelial membrane protein 1
FBN2 fibrillin 2
FGFR1 fibroblast growth factor receptor 1
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GAA glucosidase, alpha; acid
GOLT1B golgi transport 1B
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HOPX HOP homeobox
IER5 immediate early response 5
IFNGR1 interferon gamma receptor 1
IL32 interleukin 32
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
KRT7 keratin 7, type II
MAP7 microtubule-associated protein 7
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MMP7 matrix metallopeptidase 7
POR P450 (cytochrome) oxidoreductase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBP1 retinol binding protein 1, cellular
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SAT1 spermidine/spermine N1-acetyltransferase 1
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SPATA20 spermatogenesis associated 20
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STK38L serine/threonine kinase 38 like
TBX3 T-box 3
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPD52 tumor protein D52
TRDV3 T cell receptor delta variable 3
TSKU tsukushi, small leucine rich proteoglycan
TSTA3 tissue specific transplantation antigen P35B
UBE2H ubiquitin-conjugating enzyme E2H
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
ZFAND5 zinc finger, AN1-type domain 5
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ATAD2 ATPase family, AAA domain containing 2
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF132 chromosome 14 open reading frame 132
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS1B CDC28 protein kinase regulatory subunit 1B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CPOX coproporphyrinogen oxidase
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL12 chemokine (C-X-C motif) ligand 12
DCN decorin
DEK DEK proto-oncogene
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FN1 fibronectin 1
FOXM1 forkhead box M1
GALC galactosylceramidase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRAMD1C GRAM domain containing 1C
GSTZ1 glutathione S-transferase zeta 1
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMGN2 high mobility group nucleosomal binding domain 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HNMT histamine N-methyltransferase
HPRT1 hypoxanthine phosphoribosyltransferase 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGHM immunoglobulin heavy constant mu
IGLV2-23 immunoglobulin lambda variable 2-23
IL1RAP interleukin 1 receptor accessory protein
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KLHL7 kelch-like family member 7
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB1 lamin B1
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
LUM lumican
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
OLFML2B olfactomedin-like 2B
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCM1 pericentriolar material 1
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PLSCR4 phospholipid scramblase 4
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTMA prothymosin, alpha
PTTG1 pituitary tumor-transforming 1
RANBP1 RAN binding protein 1
RDX radixin
RFC4 replication factor C (activator 1) 4, 37kDa
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A6 S100 calcium binding protein A6
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRMT5 tRNA methyltransferase 5
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein
Funding