BRD-K64800655_PHA-793887_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K64800655_PHA-793887_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
AEBP1 AE binding protein 1
AHCY adenosylhomocysteinase
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD10 ankyrin repeat domain 10
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
BID BH3 interacting domain death agonist
C1S complement component 1, s subcomponent
CA2 carbonic anhydrase II
CAPN1 calpain 1, (mu/I) large subunit
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L2 chitinase 3-like 2
CIB2 calcium and integrin binding family member 2
CLDN10 claudin 10
CLIC5 chloride intracellular channel 5
COL3A1 collagen, type III, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
DSTN destrin (actin depolymerizing factor)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FKBP1B FK506 binding protein 1B, 12.6 kDa
HAPLN1 hyaluronan and proteoglycan link protein 1
HIST1H1C histone cluster 1, H1c
HOXA10 homeobox A10
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
LYZ lysozyme
MAGED1 melanoma antigen family D1
MT1E metallothionein 1E
MYL2 myosin, light chain 2, regulatory, cardiac, slow
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PI3 peptidase inhibitor 3, skin-derived
POSTN periostin, osteoblast specific factor
PRKCZ protein kinase C, zeta
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPW1 selenoprotein W, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLN sarcolipin
SNX10 sorting nexin 10
SPARCL1 SPARC-like 1 (hevin)
TNNC1 troponin C type 1 (slow)
TP53I3 tumor protein p53 inducible protein 3
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BCOR BCL6 corepressor
BMP4 bone morphogenetic protein 4
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CHD7 chromodomain helicase DNA binding protein 7
CHIC2 cysteine-rich hydrophobic domain 2
CHSY1 chondroitin sulfate synthase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CSRP2 cysteine and glycine-rich protein 2
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EGR2 early growth response 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5 eukaryotic translation initiation factor 5
FAM129A family with sequence similarity 129, member A
FZD2 frizzled class receptor 2
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIAA1551 KIAA1551
KRT15 keratin 15, type I
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP7 microtubule-associated protein 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NKX3-1 NK3 homeobox 1
NOTCH2NL notch 2 N-terminal like
NUP62 nucleoporin 62kDa
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIP prolactin-induced protein
PLK2 polo-like kinase 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RHOB ras homolog family member B
RIN2 Ras and Rab interactor 2
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD3 SMAD family member 3
SRSF7 serine/arginine-rich splicing factor 7
STX3 syntaxin 3
TACSTD2 tumor-associated calcium signal transducer 2
TBX2 T-box 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TSC22D2 TSC22 domain family, member 2
WEE1 WEE1 G2 checkpoint kinase
WLS wntless Wnt ligand secretion mediator
WSB1 WD repeat and SOCS box containing 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
Funding