BRD-K64800655_PHA-793887_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

219 genes differentially expressed following the BRD-K64800655_PHA-793887_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANKRD10 ankyrin repeat domain 10
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
CALB1 calbindin 1, 28kDa
CPT1A carnitine palmitoyltransferase 1A (liver)
CTSB cathepsin B
CXCL6 chemokine (C-X-C motif) ligand 6
DACH1 dachshund family transcription factor 1
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
EGFL6 EGF-like-domain, multiple 6
ETNK1 ethanolamine kinase 1
FASTKD5 FAST kinase domains 5
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCLC glutamate-cysteine ligase, catalytic subunit
GSTA1 glutathione S-transferase alpha 1
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HYAL1 hyaluronoglucosaminidase 1
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSR insulin receptor
IRS2 insulin receptor substrate 2
KIAA0232 KIAA0232
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KRAS Kirsten rat sarcoma viral oncogene homolog
MCOLN1 mucolipin 1
MFAP5 microfibrillar associated protein 5
MICB MHC class I polypeptide-related sequence B
MMP10 matrix metallopeptidase 10
MXI1 MAX interactor 1, dimerization protein
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NARS asparaginyl-tRNA synthetase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NLRP2 NLR family, pyrin domain containing 2
PARM1 prostate androgen-regulated mucin-like protein 1
PCDH9 protocadherin 9
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PRAME preferentially expressed antigen in melanoma
RBP1 retinol binding protein 1, cellular
RIOK3 RIO kinase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SPEN spen family transcriptional repressor
STC2 stanniocalcin 2
STK38L serine/threonine kinase 38 like
TBX3 T-box 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIMP3 TIMP metallopeptidase inhibitor 3
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM176B transmembrane protein 176B
TMEM5 transmembrane protein 5
TSPAN7 tetraspanin 7
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
AKAP7 A kinase (PRKA) anchor protein 7
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AURKA aurora kinase A
BLMH bleomycin hydrolase
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
C7 complement component 7
CA12 carbonic anhydrase XII
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNG1 cyclin G1
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CHRDL1 chordin-like 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLC Charcot-Leyden crystal galectin
CNIH4 cornichon family AMPA receptor auxiliary protein 4
CPM carboxypeptidase M
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DEFB1 defensin, beta 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DENND2D DENN/MADD domain containing 2D
EGFR epidermal growth factor receptor
EIF4A1 eukaryotic translation initiation factor 4A1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FKBP11 FK506 binding protein 11, 19 kDa
GAS1 growth arrest-specific 1
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
GZMK granzyme K (granzyme 3; tryptase II)
HMGB2 high mobility group box 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXB7 homeobox B7
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
IL7R interleukin 7 receptor
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INTS3 integrator complex subunit 3
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LAGE3 L antigen family, member 3
LAMP5 lysosomal-associated membrane protein family, member 5
LDLR low density lipoprotein receptor
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
LPL lipoprotein lipase
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
LXN latexin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MPZL2 myelin protein zero-like 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NELL2 NEL-like 2 (chicken)
NNMT nicotinamide N-methyltransferase
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPY neuropeptide Y
NUSAP1 nucleolar and spindle associated protein 1
NVL nuclear VCP-like
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PLK1 polo-like kinase 1
PLN phospholamban
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PPIB peptidylprolyl isomerase B (cyclophilin B)
PROM1 prominin 1
PTMA prothymosin, alpha
PTTG1 pituitary tumor-transforming 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RIN2 Ras and Rab interactor 2
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RPL10 ribosomal protein L10
RPS21 ribosomal protein S21
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMC4 structural maintenance of chromosomes 4
SNAP25 synaptosomal-associated protein, 25kDa
SPC25 SPC25, NDC80 kinetochore complex component
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TFF3 trefoil factor 3 (intestinal)
TGFBR3 transforming growth factor, beta receptor III
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TMPRSS3 transmembrane protease, serine 3
TNIK TRAF2 and NCK interacting kinase
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TRAC T cell receptor alpha constant
TWF2 twinfilin actin binding protein 2
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
VLDLR very low density lipoprotein receptor
VNN1 vanin 1
XBP1 X-box binding protein 1
ZWILCH zwilch kinetochore protein
Funding