BRD-K64857848_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K64857848_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CCDC85B coiled-coil domain containing 85B
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DHCR24 24-dehydrocholesterol reductase
EAF2 ELL associated factor 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPAS1 endothelial PAS domain protein 1
GFOD1 glucose-fructose oxidoreductase domain containing 1
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA2 heat shock 70kDa protein 2
IFI6 interferon, alpha-inducible protein 6
IL16 interleukin 16
KIAA1033 KIAA1033
LPIN1 lipin 1
MAP1B microtubule-associated protein 1B
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MZB1 marginal zone B and B1 cell-specific protein
NLRP2 NLR family, pyrin domain containing 2
ORM1 orosomucoid 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SELL selectin L
SPTBN1 spectrin, beta, non-erythrocytic 1
TF transferrin
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TXN thioredoxin
VWA5A von Willebrand factor A domain containing 5A
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CST1 cystatin SN
DACH1 dachshund family transcription factor 1
ECI2 enoyl-CoA delta isomerase 2
ELOVL6 ELOVL fatty acid elongase 6
FAM3C family with sequence similarity 3, member C
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSAP gamma-secretase activating protein
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HOXC6 homeobox C6
IGFBP3 insulin-like growth factor binding protein 3
JADE2 jade family PHD finger 2
LEF1 lymphoid enhancer-binding factor 1
MOK MOK protein kinase
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRN1 neuritin 1
PAM peptidylglycine alpha-amidating monooxygenase
PDAP1 PDGFA associated protein 1
PICALM phosphatidylinositol binding clathrin assembly protein
PLAT plasminogen activator, tissue
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAD23B RAD23 homolog B (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPRY2 sprouty homolog 2 (Drosophila)
SRI sorcin
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TMEM176B transmembrane protein 176B
TPBG trophoblast glycoprotein
TWIST1 twist family bHLH transcription factor 1
VCAM1 vascular cell adhesion molecule 1
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A