BRD-K64857848_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-K64857848_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
ANOS1 anosmin 1
ARG2 arginase 2
ASMTL acetylserotonin O-methyltransferase-like
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AVPI1 arginine vasopressin-induced 1
BSG basigin (Ok blood group)
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CD36 CD36 molecule (thrombospondin receptor)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC3 chloride intracellular channel 3
COG2 component of oligomeric golgi complex 2
CTH cystathionine gamma-lyase
CXADR coxsackie virus and adenovirus receptor
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP5 dual specificity phosphatase 5
EPAS1 endothelial PAS domain protein 1
FBXO21 F-box protein 21
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLNA filamin A, alpha
FOXN3 forkhead box N3
FUCA1 fucosidase, alpha-L- 1, tissue
FZD5 frizzled class receptor 5
GATA6 GATA binding protein 6
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSDMB gasdermin B
GSTA4 glutathione S-transferase alpha 4
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
JAG1 jagged 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDM3A lysine (K)-specific demethylase 3A
KIAA1033 KIAA1033
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
LGALS4 lectin, galactoside-binding, soluble, 4
LGMN legumain
LIPG lipase, endothelial
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPIN1 lipin 1
LRP4 low density lipoprotein receptor-related protein 4
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MMP12 matrix metallopeptidase 12
MXRA7 matrix-remodelling associated 7
NCAM1 neural cell adhesion molecule 1
NEB nebulin
NLRP2 NLR family, pyrin domain containing 2
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
NXN nucleoredoxin
PBX3 pre-B-cell leukemia homeobox 3
PCSK1 proprotein convertase subtilisin/kexin type 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRUNE2 prune homolog 2 (Drosophila)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QPCT glutaminyl-peptide cyclotransferase
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SIK1 salt-inducible kinase 1
SMC6 structural maintenance of chromosomes 6
SORBS1 sorbin and SH3 domain containing 1
STXBP1 syntaxin binding protein 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNNT1 troponin T type 1 (skeletal, slow)
TNS1 tensin 1
TPST2 tyrosylprotein sulfotransferase 2
TSPAN12 tetraspanin 12
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UNC13B unc-13 homolog B (C. elegans)
VAMP3 vesicle-associated membrane protein 3
VIM vimentin
WDR47 WD repeat domain 47
ZCCHC14 zinc finger, CCHC domain containing 14
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ADIRF adipogenesis regulatory factor
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANPEP alanyl (membrane) aminopeptidase
ANXA11 annexin A11
ATF1 activating transcription factor 1
B3GNT1
BHLHE41 basic helix-loop-helix family, member e41
CA12 carbonic anhydrase XII
CASP4 caspase 4, apoptosis-related cysteine peptidase
CX3CL1 chemokine (C-X3-C motif) ligand 1
DPYD dihydropyrimidine dehydrogenase
ECT2 epithelial cell transforming 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ESR1 estrogen receptor 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM129A family with sequence similarity 129, member A
FAM63A family with sequence similarity 63, member A
FHL2 four and a half LIM domains 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTO1 glutathione S-transferase omega 1
HES1 hes family bHLH transcription factor 1
HOXB2 homeobox B2
HOXB7 homeobox B7
ICAM2 intercellular adhesion molecule 2
IGF1R insulin-like growth factor 1 receptor
INTS3 integrator complex subunit 3
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB1 lamin B1
LTF lactotransferrin
LYPLA1 lysophospholipase I
METTL7A methyltransferase like 7A
MPPED2 metallophosphoesterase domain containing 2
MUC16 mucin 16, cell surface associated
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NCOA2 nuclear receptor coactivator 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
PARP2 poly (ADP-ribose) polymerase 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRR7 proline rich 7 (synaptic)
PTN pleiotrophin
PUF60 poly-U binding splicing factor 60KDa
RBMX RNA binding motif protein, X-linked
RFC3 replication factor C (activator 1) 3, 38kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SCGB1D2 secretoglobin, family 1D, member 2
SEPT9 septin 9
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SPON2 spondin 2, extracellular matrix protein
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCERG1 transcription elongation regulator 1
TM4SF1 transmembrane 4 L six family member 1
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TPBG trophoblast glycoprotein
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
Funding