BRD-K64857848_XMD-885_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-K64857848_XMD-885_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
CLDN3 claudin 3
CLU clusterin
CYR61 cysteine-rich, angiogenic inducer, 61
EGR1 early growth response 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGF13 fibroblast growth factor 13
HDAC9 histone deacetylase 9
KRT5 keratin 5, type II
MECOM MDS1 and EVI1 complex locus
NMU neuromedin U
PAX8 paired box 8
PCP4 Purkinje cell protein 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLPI secretory leukocyte peptidase inhibitor
TFPI2 tissue factor pathway inhibitor 2
TRIM2 tripartite motif containing 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP22 ubiquitin specific peptidase 22

decreased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
AEBP1 AE binding protein 1
ARG1 arginase 1
BCL2A1 BCL2-related protein A1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BGN biglycan
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CLC Charcot-Leyden crystal galectin
COCH cochlin
CXCL8 chemokine (C-X-C motif) ligand 8
DLK1 delta-like 1 homolog (Drosophila)
ENOPH1 enolase-phosphatase 1
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GATA3 GATA binding protein 3
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
INHBA inhibin, beta A
LYPD3 LY6/PLAUR domain containing 3
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NID1 nidogen 1
NPTX2 neuronal pentraxin II
PCOLCE procollagen C-endopeptidase enhancer
PPAP2B phosphatidic acid phosphatase type 2B
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RBP1 retinol binding protein 1, cellular
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SPON2 spondin 2, extracellular matrix protein
SQRDL sulfide quinone reductase-like (yeast)
TF transferrin
TM4SF1 transmembrane 4 L six family member 1
TSPAN4 tetraspanin 4
VCAN versican
Funding