BRD-K64881305_S1452_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K64881305_S1452_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
BST2 bone marrow stromal cell antigen 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CDC20 cell division cycle 20
CLIC3 chloride intracellular channel 3
CPVL carboxypeptidase, vitellogenic-like
CXCL3 chemokine (C-X-C motif) ligand 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2BK histone cluster 1, H2bk
HOXC6 homeobox C6
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LDLR low density lipoprotein receptor
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OASL 2'-5'-oligoadenylate synthetase-like
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
STAT1 signal transducer and activator of transcription 1, 91kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX2 T-box 2
TLR4 toll-like receptor 4
TM7SF2 transmembrane 7 superfamily member 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6

decreased expression

Symbol Name
BTG3 BTG family, member 3
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
DLD dihydrolipoamide dehydrogenase
GRB7 growth factor receptor-bound protein 7
LOXL1 lysyl oxidase-like 1
MCM3 minichromosome maintenance complex component 3
MGLL monoglyceride lipase
MUC16 mucin 16, cell surface associated
NXN nucleoredoxin
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
RANBP1 RAN binding protein 1
RGCC regulator of cell cycle
RRM2 ribonucleotide reductase M2
SNX7 sorting nexin 7
STS steroid sulfatase (microsomal), isozyme S
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
VTCN1 V-set domain containing T cell activation inhibitor 1
ZNF395 zinc finger protein 395
Funding