BRD-K64890080_BI 2536_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

266 genes differentially expressed following the BRD-K64890080_BI 2536_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND1 cyclin D1
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CES1 carboxylesterase 1
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL4A6 collagen, type IV, alpha 6
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CREM cAMP responsive element modulator
CSRNP2 cysteine-serine-rich nuclear protein 2
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DZIP3 DAZ interacting zinc finger protein 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR3 fibroblast growth factor receptor 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GPC3 glypican 3
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IGSF1 immunoglobulin superfamily, member 1
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
JAK1 Janus kinase 1
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAM1 neural cell adhesion molecule 1
NDNF neuron-derived neurotrophic factor
NDRG4 NDRG family member 4
NLRP2 NLR family, pyrin domain containing 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
PDPK1 3-phosphoinositide dependent protein kinase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNMA1 paraneoplastic Ma antigen 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
PTPN12 protein tyrosine phosphatase, non-receptor type 12
REEP1 receptor accessory protein 1
RGS13 regulator of G-protein signaling 13
RHOBTB3 Rho-related BTB domain containing 3
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SST somatostatin
STXBP1 syntaxin binding protein 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TIAM1 T-cell lymphoma invasion and metastasis 1
TKTL1 transketolase-like 1
TMEM2 transmembrane protein 2
USP11 ubiquitin specific peptidase 11
WDR47 WD repeat domain 47
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACAT1 acetyl-CoA acetyltransferase 1
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRE5 adhesion G protein-coupled receptor E5
AHCY adenosylhomocysteinase
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALG3 ALG3, alpha-1,3- mannosyltransferase
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
AMD1 adenosylmethionine decarboxylase 1
ANXA11 annexin A11
APRT adenine phosphoribosyltransferase
AQP3 aquaporin 3 (Gill blood group)
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATF1 activating transcription factor 1
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHE41 basic helix-loop-helix family, member e41
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
CANT1 calcium activated nucleotidase 1
CBS cystathionine-beta-synthase
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
COMT catechol-O-methyltransferase
CP ceruloplasmin (ferroxidase)
CTPS1 CTP synthase 1
DCN decorin
DCTD dCMP deaminase
DCXR dicarbonyl/L-xylulose reductase
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKC1 dyskeratosis congenita 1, dyskerin
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPH2 DPH2 homolog (S. cerevisiae)
DUS1L dihydrouridine synthase 1-like (S. cerevisiae)
EIF4B eukaryotic translation initiation factor 4B
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
F12 coagulation factor XII (Hageman factor)
FAM216A family with sequence similarity 216, member A
FAM60A family with sequence similarity 60, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FKBP11 FK506 binding protein 11, 19 kDa
FTO fat mass and obesity associated
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GSTT1 glutathione S-transferase theta 1
GTF3A general transcription factor IIIA
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOMER2 homer scaffolding protein 2
HOXC6 homeobox C6
HPN hepsin
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS isoleucyl-tRNA synthetase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ISOC2 isochorismatase domain containing 2
ITGB5 integrin, beta 5
KRT18 keratin 18, type I
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LYRM4 LYR motif containing 4
MACROD1 MACRO domain containing 1
MAOA monoamine oxidase A
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK13 mitogen-activated protein kinase 13
MGST2 microsomal glutathione S-transferase 2
MLPH melanophilin
MRPL11 mitochondrial ribosomal protein L11
MRPL12 mitochondrial ribosomal protein L12
MRPL23 mitochondrial ribosomal protein L23
MRPL24 mitochondrial ribosomal protein L24
MRPL3 mitochondrial ribosomal protein L3
MRPS35 mitochondrial ribosomal protein S35
MTA1 metastasis associated 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NET1 neuroepithelial cell transforming 1
NHP2 NHP2 ribonucleoprotein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
ODC1 ornithine decarboxylase 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDLIM5 PDZ and LIM domain 5
PFAS phosphoribosylformylglycinamidine synthase
PFKP phosphofructokinase, platelet
PLAT plasminogen activator, tissue
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLS3 plastin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POSTN periostin, osteoblast specific factor
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRDX3 peroxiredoxin 3
PRDX4 peroxiredoxin 4
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PUS7 pseudouridylate synthase 7 (putative)
PYCR1 pyrroline-5-carboxylate reductase 1
RAB25 RAB25, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RAP1GAP RAP1 GTPase activating protein
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL31 ribosomal protein L31
RPS11 ribosomal protein S11
RSL1D1 ribosomal L1 domain containing 1
SFXN1 sideroflexin 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC35F2 solute carrier family 35, member F2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS2 sorbin and SH3 domain containing 2
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPATA20 spermatogenesis associated 20
SPDEF SAM pointed domain containing ETS transcription factor
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
ST7 suppression of tumorigenicity 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STRA13 stimulated by retinoic acid 13
SYNGR2 synaptogyrin 2
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARP TCR gamma alternate reading frame protein
TCERG1 transcription elongation regulator 1
THBS2 thrombospondin 2
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLK1 tousled-like kinase 1
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TP53 tumor protein p53
TRIM14 tripartite motif containing 14
TRIP13 thyroid hormone receptor interactor 13
TRIP6 thyroid hormone receptor interactor 6
TXN thioredoxin
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCK2 uridine-cytidine kinase 2
URI1 URI1, prefoldin-like chaperone
VCAN versican
WDR12 WD repeat domain 12
WDR43 WD repeat domain 43
WFDC2 WAP four-disulfide core domain 2
YIF1A Yip1 interacting factor homolog A (S. cerevisiae)
Funding