BRD-K64890080_BI 2536_WSUDLCL2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-K64890080_BI 2536_WSUDLCL2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY9 adenylate cyclase 9
ADI1 acireductone dioxygenase 1
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AOX1 aldehyde oxidase 1
APMAP adipocyte plasma membrane associated protein
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFD complement factor D (adipsin)
CIRBP cold inducible RNA binding protein
CTH cystathionine gamma-lyase
DAAM2 dishevelled associated activator of morphogenesis 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS2 dehydrogenase/reductase (SDR family) member 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FILIP1L filamin A interacting protein 1-like
FLRT2 fibronectin leucine rich transmembrane protein 2
GDE1 glycerophosphodiester phosphodiesterase 1
GLCE glucuronic acid epimerase
GPX4 glutathione peroxidase 4
GSDMB gasdermin B
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HN1 hematological and neurological expressed 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
ITSN1 intersectin 1 (SH3 domain protein)
KDM3A lysine (K)-specific demethylase 3A
KIAA1033 KIAA1033
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS4 lectin, galactoside-binding, soluble, 4
LGMN legumain
LPL lipoprotein lipase
MTSS1 metastasis suppressor 1
NMU neuromedin U
NOSIP nitric oxide synthase interacting protein
NPR3 natriuretic peptide receptor 3
NRGN neurogranin (protein kinase C substrate, RC3)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK5 proprotein convertase subtilisin/kexin type 5
PEG3 paternally expressed 3
PKP2 plakophilin 2
PLA2G16 phospholipase A2, group XVI
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN1 perilipin 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF130 ring finger protein 130
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERINC5 serine incorporator 5
SGK1 serum/glucocorticoid regulated kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
STAR steroidogenic acute regulatory protein
STK38 serine/threonine kinase 38
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TKTL1 transketolase-like 1
TLR4 toll-like receptor 4
TRIM36 tripartite motif containing 36
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VAMP3 vesicle-associated membrane protein 3
ZCCHC14 zinc finger, CCHC domain containing 14
ZNF451 zinc finger protein 451
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADGRE5 adhesion G protein-coupled receptor E5
AES amino-terminal enhancer of split
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATXN10 ataxin 10
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CD48 CD48 molecule
CD69 CD69 molecule
CDC45 cell division cycle 45
CDK14 cyclin-dependent kinase 14
CP ceruloplasmin (ferroxidase)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DCTD dCMP deaminase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
EVL Enah/Vasp-like
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
GTF3A general transcription factor IIIA
HOXA10 homeobox A10
IFRD2 interferon-related developmental regulator 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IPO5 importin 5
ITGB1BP1 integrin beta 1 binding protein 1
JADE2 jade family PHD finger 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0101 KIAA0101
KIAA0125 KIAA0125
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAK16 MAK16 homolog (S. cerevisiae)
MAT2A methionine adenosyltransferase II, alpha
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPL3 mitochondrial ribosomal protein L3
MUC16 mucin 16, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME1 NME/NM23 nucleoside diphosphate kinase 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARVB parvin, beta
PAX5 paired box 5
PDLIM5 PDZ and LIM domain 5
PERP PERP, TP53 apoptosis effector
PFN2 profilin 2
PIH1D1 PIH1 domain containing 1
POU2AF1 POU class 2 associating factor 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAMD4A sterile alpha motif domain containing 4A
SCEL sciellin
SEPT9 septin 9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SMYD2 SET and MYND domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
STAP1 signal transducing adaptor family member 1
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE2 transducin-like enhancer of split 2
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TNC tenascin C
TNS3 tensin 3
TTR transthyretin
UBE2E1 ubiquitin-conjugating enzyme E2E 1
VCAN versican
XPO7 exportin 7
YME1L1 YME1-like 1 ATPase
ZMIZ1 zinc finger, MIZ-type containing 1
Funding