BRD-K64890080_BI-2536_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

251 genes differentially expressed following the BRD-K64890080_BI-2536_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AACS acetoacetyl-CoA synthetase
ACKR3 atypical chemokine receptor 3
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOC aldolase C, fructose-bisphosphate
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASMTL acetylserotonin O-methyltransferase-like
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC92 coiled-coil domain containing 92
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHN2 chimerin 2
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL14A1 collagen, type XIV, alpha 1
CTH cystathionine gamma-lyase
CXADR coxsackie virus and adenovirus receptor
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM50A family with sequence similarity 50, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FKBP14 FK506 binding protein 14, 22 kDa
FNBP1 formin binding protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GPNMB glycoprotein (transmembrane) nmb
GSTA4 glutathione S-transferase alpha 4
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IFNGR1 interferon gamma receptor 1
IGF2R insulin-like growth factor 2 receptor
INSIG1 insulin induced gene 1
IQGAP1 IQ motif containing GTPase activating protein 1
JAK1 Janus kinase 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KIAA0513 KIAA0513
KIF2C kinesin family member 2C
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LGMN legumain
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAN1A1 mannosidase, alpha, class 1A, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP10 matrix metallopeptidase 10
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
MYO1B myosin IB
MYO1D myosin ID
NCK1 NCK adaptor protein 1
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NID2 nidogen 2 (osteonidogen)
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH9 protocadherin 9
PCYOX1 prenylcysteine oxidase 1
PEG10 paternally expressed 10
PGD phosphogluconate dehydrogenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLK2 polo-like kinase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAP prosaposin
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
RIOK3 RIO kinase 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SSBP2 single-stranded DNA binding protein 2
STC1 stanniocalcin 1
STX12 syntaxin 12
STXBP1 syntaxin binding protein 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TGFBR3 transforming growth factor, beta receptor III
TM7SF2 transmembrane 7 superfamily member 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TUFT1 tuftelin 1
TUSC3 tumor suppressor candidate 3
VLDLR very low density lipoprotein receptor
VSNL1 visinin-like 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF1 activating transcription factor 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCNA2 cyclin A2
CCNB1 cyclin B1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25A cell division cycle 25A
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
COL3A1 collagen, type III, alpha 1
CTSG cathepsin G
ERBB3 erb-b2 receptor tyrosine kinase 3
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
FXYD5 FXYD domain containing ion transport regulator 5
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPR171 G protein-coupled receptor 171
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB2 high mobility group box 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXB7 homeobox B7
HSPB1 heat shock 27kDa protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KRT18 keratin 18, type I
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MECOM MDS1 and EVI1 complex locus
MFAP2 microfibrillar-associated protein 2
MOK MOK protein kinase
MRPL15 mitochondrial ribosomal protein L15
MRPS28 mitochondrial ribosomal protein S28
NDC80 NDC80 kinetochore complex component
NES nestin
NOP16 NOP16 nucleolar protein
NUCB2 nucleobindin 2
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PLAC8 placenta-specific 8
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PUF60 poly-U binding splicing factor 60KDa
PYCR1 pyrroline-5-carboxylate reductase 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RRM1 ribonucleotide reductase M1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC38A1 solute carrier family 38, member 1
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
SRI sorcin
SRSF1 serine/arginine-rich splicing factor 1
SSBP1 single-stranded DNA binding protein 1, mitochondrial
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TARP TCR gamma alternate reading frame protein
TEX10 testis expressed 10
TIPIN TIMELESS interacting protein
TLR4 toll-like receptor 4
TMEM176B transmembrane protein 176B
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TYMS thymidylate synthetase
VCAN versican
ZDHHC6 zinc finger, DHHC-type containing 6
Funding