BRD-K64890080_BI-2536_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-K64890080_BI-2536_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA1 annexin A1
ATPIF1 ATPase inhibitory factor 1
AURKA aurora kinase A
BMP7 bone morphogenetic protein 7
CCND2 cyclin D2
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA1 chloride channel accessory 1
CLEC2B C-type lectin domain family 2, member B
CLGN calmegin
CXADR coxsackie virus and adenovirus receptor
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
FAM169A family with sequence similarity 169, member A
FBN2 fibrillin 2
G0S2 G0/G1 switch 2
H2AFY H2A histone family, member Y
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL13RA2 interleukin 13 receptor, alpha 2
ITGA6 integrin, alpha 6
KCTD12 potassium channel tetramerization domain containing 12
KIF14 kinesin family member 14
LAMB1 laminin, beta 1
LCN2 lipocalin 2
LYN LYN proto-oncogene, Src family tyrosine kinase
LYPD1 LY6/PLAUR domain containing 1
MMP10 matrix metallopeptidase 10
MUC2 mucin 2, oligomeric mucus/gel-forming
NARF nuclear prelamin A recognition factor
NARFL nuclear prelamin A recognition factor-like
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
NTS neurotensin
PARP8 poly (ADP-ribose) polymerase family, member 8
PAX8 paired box 8
PHLDA1 pleckstrin homology-like domain, family A, member 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLPI secretory leukocyte peptidase inhibitor
SNX10 sorting nexin 10
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
STAR steroidogenic acute regulatory protein
TERT telomerase reverse transcriptase
TFF1 trefoil factor 1
THEMIS2 thymocyte selection associated family member 2
TNIK TRAF2 and NCK interacting kinase
TOB1 transducer of ERBB2, 1
TSPAN13 tetraspanin 13
VNN1 vanin 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
ANK2 ankyrin 2, neuronal
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C10ORF10 chromosome 10 open reading frame 10
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CCNE2 cyclin E2
CDK1 cyclin-dependent kinase 1
CFLAR CASP8 and FADD-like apoptosis regulator
CH25H cholesterol 25-hydroxylase
CNN1 calponin 1, basic, smooth muscle
COL14A1 collagen, type XIV, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DCN decorin
DDT D-dopachrome tautomerase
DHCR7 7-dehydrocholesterol reductase
DPT dermatopontin
DPYSL2 dihydropyrimidinase-like 2
EDN1 endothelin 1
EGF epidermal growth factor
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR2 early growth response 2
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FMO2 flavin containing monooxygenase 2 (non-functional)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM1 intercellular adhesion molecule 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
ITM2A integral membrane protein 2A
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LUM lumican
MAPT microtubule-associated protein tau
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDN necdin, melanoma antigen (MAGE) family member
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NREP neuronal regeneration related protein
OLFML2A olfactomedin-like 2A
OLFML3 olfactomedin-like 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLN phospholamban
POSTN periostin, osteoblast specific factor
PPIF peptidylprolyl isomerase F
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS23 protease, serine, 23
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PYCR1 pyrroline-5-carboxylate reductase 1
RAB25 RAB25, member RAS oncogene family
RGS4 regulator of G-protein signaling 4
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE4 ribonuclease, RNase A family, 4
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELE selectin E
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SH3YL1 SH3 and SYLF domain containing 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLURP1 secreted LY6/PLAUR domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TACSTD2 tumor-associated calcium signal transducer 2
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMSB15A thymosin beta 15a
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNS1 tensin 1
TOPBP1 topoisomerase (DNA) II binding protein 1
TRIM16 tripartite motif containing 16
TSPAN8 tetraspanin 8
TUFT1 tuftelin 1
VCAM1 vascular cell adhesion molecule 1
WEE1 WEE1 G2 checkpoint kinase
ZWINT ZW10 interacting kinetochore protein
Funding