BRD-K64890080_BI-2536_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

253 genes differentially expressed following the BRD-K64890080_BI-2536_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAT1 adenosine deaminase, tRNA-specific 1
AK1 adenylate kinase 1
AKIRIN1 akirin 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATPIF1 ATPase inhibitory factor 1
BAMBI BMP and activin membrane-bound inhibitor
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CCDC85B coiled-coil domain containing 85B
CD24 CD24 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CIRBP cold inducible RNA binding protein
CREG1 cellular repressor of E1A-stimulated genes 1
CXADR coxsackie virus and adenovirus receptor
CYB5R1 cytochrome b5 reductase 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DLX5 distal-less homeobox 5
DUSP6 dual specificity phosphatase 6
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
ELOVL5 ELOVL fatty acid elongase 5
EPAS1 endothelial PAS domain protein 1
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FAM117A family with sequence similarity 117, member A
FAM46A family with sequence similarity 46, member A
FAM50A family with sequence similarity 50, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
G0S2 G0/G1 switch 2
G6PD glucose-6-phosphate dehydrogenase
GATA3 GATA binding protein 3
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HDAC1 histone deacetylase 1
HIP1R huntingtin interacting protein 1 related
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
JAK1 Janus kinase 1
JUN jun proto-oncogene
KIAA0513 KIAA0513
KIF2C kinesin family member 2C
KYNU kynureninase
LAGE3 L antigen family, member 3
LCN2 lipocalin 2
MARCKSL1 MARCKS-like 1
METTL7A methyltransferase like 7A
MYO1B myosin IB
NARF nuclear prelamin A recognition factor
NEBL nebulette
NELL2 NEL-like 2 (chicken)
NEU1 sialidase 1 (lysosomal sialidase)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
ORM1 orosomucoid 1
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCDH17 protocadherin 17
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG10 paternally expressed 10
PIAS1 protein inhibitor of activated STAT, 1
POR P450 (cytochrome) oxidoreductase
POU4F1 POU class 4 homeobox 1
PPAP2B phosphatidic acid phosphatase type 2B
PSAP prosaposin
RAB31 RAB31, member RAS oncogene family
RALBP1 ralA binding protein 1
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SFTPC surfactant protein C
SKAP2 src kinase associated phosphoprotein 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TDRD7 tudor domain containing 7
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TXNRD1 thioredoxin reductase 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRG1 adhesion G protein-coupled receptor G1
AES amino-terminal enhancer of split
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF1 activating transcription factor 1
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BHMT betaine--homocysteine S-methyltransferase
CA12 carbonic anhydrase XII
CALB1 calbindin 1, 28kDa
CALD1 caldesmon 1
CALR calreticulin
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCR7 chemokine (C-C motif) receptor 7
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN8 claudin 8
CNN1 calponin 1, basic, smooth muscle
COCH cochlin
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DEFB1 defensin, beta 1
DENND2D DENN/MADD domain containing 2D
DMD dystrophin
DPYSL3 dihydropyrimidinase-like 3
DRAM1 DNA-damage regulated autophagy modulator 1
DUT deoxyuridine triphosphatase
EDN1 endothelin 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFS embryonal Fyn-associated substrate
EGF epidermal growth factor
EMP3 epithelial membrane protein 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FBN1 fibrillin 1
FKBP11 FK506 binding protein 11, 19 kDa
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
ICAM1 intercellular adhesion molecule 1
ICAM3 intercellular adhesion molecule 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IL32 interleukin 32
IL7R interleukin 7 receptor
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0101 KIAA0101
KRT4 keratin 4, type II
LMNB1 lamin B1
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
MRPL15 mitochondrial ribosomal protein L15
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTMR2 myotubularin related protein 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP16 NOP16 nucleolar protein
NOX4 NADPH oxidase 4
NREP neuronal regeneration related protein
OLFML3 olfactomedin-like 3
P3H2 prolyl 3-hydroxylase 2
PDGFC platelet derived growth factor C
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM5 PDZ and LIM domain 5
PFAS phosphoribosylformylglycinamidine synthase
PHGDH phosphoglycerate dehydrogenase
PLBD1 phospholipase B domain containing 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRSS23 protease, serine, 23
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTER phosphotriesterase related
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBPMS RNA binding protein with multiple splicing
RCN1 reticulocalbin 1, EF-hand calcium binding domain
S100A2 S100 calcium binding protein A2
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC35F2 solute carrier family 35, member F2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMAD1 SMAD family member 1
SMCO4 single-pass membrane protein with coiled-coil domains 4
SORBS3 sorbin and SH3 domain containing 3
SYNPO synaptopodin
TFPI2 tissue factor pathway inhibitor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TM4SF1 transmembrane 4 L six family member 1
TMEM176B transmembrane protein 176B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNS1 tensin 1
TPM1 tropomyosin 1 (alpha)
TUBB tubulin, beta class I
TYMS thymidylate synthetase
VCAM1 vascular cell adhesion molecule 1
VCAN versican
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein
Funding