BRD-K64890080_BI-2536_HME1_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K64890080_BI-2536_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA4 annexin A4
ATF3 activating transcription factor 3
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CPM carboxypeptidase M
CTH cystathionine gamma-lyase
CTSH cathepsin H
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR3 early growth response 3
ELOVL5 ELOVL fatty acid elongase 5
FILIP1L filamin A interacting protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
JUNB jun B proto-oncogene
KIF2C kinesin family member 2C
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
LAMP2 lysosomal-associated membrane protein 2
LAMP5 lysosomal-associated membrane protein family, member 5
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
MEIS2 Meis homeobox 2
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MSX1 msh homeobox 1
MYO6 myosin VI
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMU neuromedin U
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCNA proliferating cell nuclear antigen
PELI1 pellino E3 ubiquitin protein ligase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTCH1 patched 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SRSF7 serine/arginine-rich splicing factor 7
TBX2 T-box 2
TMEM2 transmembrane protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ASPH aspartate beta-hydroxylase
ATF1 activating transcription factor 1
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
CAPN2 calpain 2, (m/II) large subunit
CCNB1 cyclin B1
CCND2 cyclin D2
CCNF cyclin F
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
FAM129A family with sequence similarity 129, member A
GLIPR1 GLI pathogenesis-related 1
GOLGA8A golgin A8 family, member A
HBB hemoglobin, beta
IL1B interleukin 1, beta
JADE2 jade family PHD finger 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLHL9 kelch-like family member 9
KRT7 keratin 7, type II
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MET MET proto-oncogene, receptor tyrosine kinase
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
PLAC8 placenta-specific 8
POU2AF1 POU class 2 associating factor 1
RAD23B RAD23 homolog B (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB2A2 secretoglobin, family 2A, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding