BRD-K64890080_BI-2536_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K64890080_BI-2536_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALB albumin
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNB2 cyclin B2
CCND2 cyclin D2
CDC20 cell division cycle 20
CENPE centromere protein E, 312kDa
CKAP2 cytoskeleton associated protein 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLGN calmegin
CLMN calmin (calponin-like, transmembrane)
CNOT4 CCR4-NOT transcription complex, subunit 4
CTSV cathepsin V
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FZD7 frizzled class receptor 7
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA3 GATA binding protein 3
GHR growth hormone receptor
HIST1H2AC histone cluster 1, H2ac
HMG20B high mobility group 20B
HMMR hyaluronan-mediated motility receptor (RHAMM)
IQCG IQ motif containing G
ITGA6 integrin, alpha 6
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAGE3 L antigen family, member 3
LAMB1 laminin, beta 1
LOC100286895 cell division cycle 27 homolog pseudogene
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MDC1 mediator of DNA-damage checkpoint 1
MMD monocyte to macrophage differentiation-associated
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NELL2 NEL-like 2 (chicken)
NFE2L3 nuclear factor, erythroid 2-like 3
NRN1 neuritin 1
PADI2 peptidyl arginine deiminase, type II
PAN2 PAN2 poly(A) specific ribonuclease subunit
PLK1 polo-like kinase 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SPA17 sperm autoantigenic protein 17
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STC1 stanniocalcin 1
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TXNIP thioredoxin interacting protein
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF165 zinc finger protein 165
ZNF318 zinc finger protein 318
ZNF589 zinc finger protein 589
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL6 B-cell CLL/lymphoma 6
C10ORF10 chromosome 10 open reading frame 10
C1S complement component 1, s subcomponent
CALD1 caldesmon 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CD24 CD24 molecule
CD58 CD58 molecule
CD99 CD99 molecule
CLU clusterin
CREB1 cAMP responsive element binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
FADS1 fatty acid desaturase 1
FAS Fas cell surface death receptor
FRY furry homolog (Drosophila)
GBP1 guanylate binding protein 1, interferon-inducible
GSTT1 glutathione S-transferase theta 1
HOPX HOP homeobox
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFITM3 interferon induced transmembrane protein 3
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL1R1 interleukin 1 receptor, type I
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLF6 Kruppel-like factor 6
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
LAMB3 laminin, beta 3
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MCM3 minichromosome maintenance complex component 3
MEIS1 Meis homeobox 1
MPO myeloperoxidase
MPZL2 myelin protein zero-like 2
NOV nephroblastoma overexpressed
NREP neuronal regeneration related protein
NUPR1 nuclear protein, transcriptional regulator, 1
PLN phospholamban
PNMA2 paraneoplastic Ma antigen 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBMS1 RNA binding motif, single stranded interacting protein 1
RGS13 regulator of G-protein signaling 13
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SAMD4A sterile alpha motif domain containing 4A
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOX11 SRY (sex determining region Y)-box 11
SPARCL1 SPARC-like 1 (hevin)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VAT1 vesicle amine transport 1
WEE1 WEE1 G2 checkpoint kinase
WNT5A wingless-type MMTV integration site family, member 5A
Funding