BRD-K64890080_BI-2536_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-K64890080_BI-2536_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACACB acetyl-CoA carboxylase beta
ACTC1 actin, alpha, cardiac muscle 1
ADD3 adducin 3 (gamma)
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ASCL1 achaete-scute family bHLH transcription factor 1
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CALCA calcitonin-related polypeptide alpha
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL13A1 collagen, type XIII, alpha 1
COLEC12 collectin sub-family member 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EDN3 endothelin 3
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
FAM46A family with sequence similarity 46, member A
FAM50A family with sequence similarity 50, member A
FBXO21 F-box protein 21
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPM6B glycoprotein M6B
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HSPA1A heat shock 70kDa protein 1A
IER5 immediate early response 5
IFI30 interferon, gamma-inducible protein 30
INSIG1 insulin induced gene 1
JAG1 jagged 1
JAK1 Janus kinase 1
KIAA1033 KIAA1033
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LGMN legumain
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRP4 low density lipoprotein receptor-related protein 4
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTBP1 latent transforming growth factor beta binding protein 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAST2 microtubule associated serine/threonine kinase 2
MATN2 matrilin 2
NDRG1 N-myc downstream regulated 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
RBM25 RNA binding motif protein 25
RPS4Y1 ribosomal protein S4, Y-linked 1
SC5D sterol-C5-desaturase
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SIX1 SIX homeobox 1
SNAP23 synaptosomal-associated protein, 23kDa
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQLE squalene epoxidase
SRPX sushi-repeat containing protein, X-linked
STXBP1 syntaxin binding protein 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM2 transmembrane protein 2
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
AADAC arylacetamide deacetylase
ABLIM1 actin binding LIM protein 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C3 aldo-keto reductase family 1, member C3
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA1 annexin A1
APOC2 apolipoprotein C-II
ARG1 arginase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPN asporin
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
CCL19 chemokine (C-C motif) ligand 19
CD200 CD200 molecule
CD58 CD58 molecule
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFB complement factor B
CFH complement factor H
CFI complement factor I
CFLAR CASP8 and FADD-like apoptosis regulator
CRYZ crystallin, zeta (quinone reductase)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EREG epiregulin
ERH enhancer of rudimentary homolog (Drosophila)
ESR1 estrogen receptor 1
F5 coagulation factor V (proaccelerin, labile factor)
FAM129A family with sequence similarity 129, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
IFITM1 interferon induced transmembrane protein 1
JADE2 jade family PHD finger 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLK10 kallikrein-related peptidase 10
KRT18 keratin 18, type I
KRT23 keratin 23, type I
LHX2 LIM homeobox 2
LOXL1 lysyl oxidase-like 1
MANSC1 MANSC domain containing 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MCTP1 multiple C2 domains, transmembrane 1
MDK midkine (neurite growth-promoting factor 2)
MGST2 microsomal glutathione S-transferase 2
MMP7 matrix metallopeptidase 7
MNDA myeloid cell nuclear differentiation antigen
MPZL2 myelin protein zero-like 2
MRPL3 mitochondrial ribosomal protein L3
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5C myosin VC
MYRF myelin regulatory factor
NDRG2 NDRG family member 2
NREP neuronal regeneration related protein
OLFM4 olfactomedin 4
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
POMZP3 POM121 and ZP3 fusion
PON2 paraoxonase 2
PPAP2C phosphatidic acid phosphatase type 2C
PRKCA protein kinase C, alpha
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51C RAD51 paralog C
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCEL sciellin
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS2 sorbin and SH3 domain containing 2
SORD sorbitol dehydrogenase
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TFR2 transferrin receptor 2
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TMEM176B transmembrane protein 176B
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM14 tripartite motif containing 14
TRIP6 thyroid hormone receptor interactor 6
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
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