BRD-K64890080_BI-2536_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

266 genes differentially expressed following the BRD-K64890080_BI-2536_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
ATF3 activating transcription factor 3
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC92 coiled-coil domain containing 92
CCK cholecystokinin
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CDC25B cell division cycle 25B
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CIRBP cold inducible RNA binding protein
CLSTN1 calsyntenin 1
COL2A1 collagen, type II, alpha 1
COMP cartilage oligomeric matrix protein
CTSB cathepsin B
CTSL cathepsin L
CTSV cathepsin V
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DUSP14 dual specificity phosphatase 14
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP4 fatty acid binding protein 4, adipocyte
FADS2 fatty acid desaturase 2
FAM46A family with sequence similarity 46, member A
FAM50A family with sequence similarity 50, member A
FBXO21 F-box protein 21
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GDI1 GDP dissociation inhibitor 1
GLS glutaminase
GM2A GM2 ganglioside activator
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
JAK1 Janus kinase 1
JARID2 jumonji, AT rich interactive domain 2
KIAA1033 KIAA1033
KIF2C kinesin family member 2C
KLK5 kallikrein-related peptidase 5
KRT15 keratin 15, type I
LAMP3 lysosomal-associated membrane protein 3
LGMN legumain
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MSMO1 methylsterol monooxygenase 1
MYO1B myosin IB
NEFH neurofilament, heavy polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
PINK1 PTEN induced putative kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTTG1IP pituitary tumor-transforming 1 interacting protein
RAP2A RAP2A, member of RAS oncogene family
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGC Ras-related GTP binding C
RYBP RING1 and YY1 binding protein
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SNAP23 synaptosomal-associated protein, 23kDa
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQLE squalene epoxidase
STOM stomatin
STXBP1 syntaxin binding protein 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TDRD7 tudor domain containing 7
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TXNRD1 thioredoxin reductase 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WWC3 WWC family member 3

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ABLIM1 actin binding LIM protein 1
ADGRE5 adhesion G protein-coupled receptor E5
ADORA2B adenosine A2b receptor
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK2 ankyrin 2, neuronal
ANXA1 annexin A1
ANXA10 annexin A10
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF1 activating transcription factor 1
BHLHE41 basic helix-loop-helix family, member e41
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAST calpastatin
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK1 cyclin-dependent kinase 1
CDK14 cyclin-dependent kinase 14
CDK4 cyclin-dependent kinase 4
CFH complement factor H
CFI complement factor I
CHL1 cell adhesion molecule L1-like
CP ceruloplasmin (ferroxidase)
CRYZ crystallin, zeta (quinone reductase)
CTSH cathepsin H
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYD dihydropyrimidine dehydrogenase
ECHDC2 enoyl CoA hydratase domain containing 2
EGFR epidermal growth factor receptor
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
EVL Enah/Vasp-like
F12 coagulation factor XII (Hageman factor)
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FHIT fragile histidine triad
FXYD5 FXYD domain containing ion transport regulator 5
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP2 guanylate binding protein 2, interferon-inducible
GPM6A glycoprotein M6A
GSAP gamma-secretase activating protein
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPB1 heat shock 27kDa protein 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP4 insulin-like growth factor binding protein 4
IGKV4-1 immunoglobulin kappa variable 4-1
ITK IL2-inducible T-cell kinase
JADE2 jade family PHD finger 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT4 keratin 4, type II
KRT7 keratin 7, type II
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LPAR1 lysophosphatidic acid receptor 1
LTF lactotransferrin
MAL mal, T-cell differentiation protein
MCM5 minichromosome maintenance complex component 5
MCTP1 multiple C2 domains, transmembrane 1
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
METTL1 methyltransferase like 1
METTL21B methyltransferase like 21B
MGST2 microsomal glutathione S-transferase 2
MPZL2 myelin protein zero-like 2
MRPL19 mitochondrial ribosomal protein L19
MRPL3 mitochondrial ribosomal protein L3
MRPS30 mitochondrial ribosomal protein S30
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYRF myelin regulatory factor
N4BP2L2 NEDD4 binding protein 2-like 2
NAMPT nicotinamide phosphoribosyltransferase
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NFE2L3 nuclear factor, erythroid 2-like 3
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NREP neuronal regeneration related protein
PAM peptidylglycine alpha-amidating monooxygenase
PDE4B phosphodiesterase 4B, cAMP-specific
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRDX2 peroxiredoxin 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RAB25 RAB25, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
REPIN1 replication initiator 1
RHOBTB3 Rho-related BTB domain containing 3
RNASE4 ribonuclease, RNase A family, 4
RPIA ribose 5-phosphate isomerase A
S100A12 S100 calcium binding protein A12
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCEL sciellin
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAGP small cell adhesion glycoprotein
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS2 sorbin and SH3 domain containing 2
SORD sorbitol dehydrogenase
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SRP72 signal recognition particle 72kDa
SRPRB signal recognition particle receptor, B subunit
STEAP3 STEAP family member 3, metalloreductase
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRBC1 T cell receptor beta constant 1
TRIM14 tripartite motif containing 14
TRIP6 thyroid hormone receptor interactor 6
TSPO translocator protein (18kDa)
UBE2C ubiquitin-conjugating enzyme E2C
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UNG uracil-DNA glycosylase
VCAN versican
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)
Funding