BRD-K64890080_BI-2536_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K64890080_BI-2536_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AURKA aurora kinase A
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB2 cyclin B2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DLC1 DLC1 Rho GTPase activating protein
DUSP1 dual specificity phosphatase 1
EGR3 early growth response 3
FERMT2 fermitin family member 2
FLNB filamin B, beta
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXO1 forkhead box O1
FXR1 fragile X mental retardation, autosomal homolog 1
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PCDH9 protocadherin 9
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RNF114 ring finger protein 114
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
SPTAN1 spectrin, alpha, non-erythrocytic 1
TRAM2 translocation associated membrane protein 2
TUBB6 tubulin, beta 6 class V
WT1 Wilms tumor 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA4 annexin A4
ANXA9 annexin A9
CALML3 calmodulin-like 3
CAPG capping protein (actin filament), gelsolin-like
CCNE2 cyclin E2
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CTSH cathepsin H
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCK deoxycytidine kinase
EAPP E2F-associated phosphoprotein
EFS embryonal Fyn-associated substrate
ETV1 ets variant 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP3 insulin-like growth factor binding protein 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
ISG15 ISG15 ubiquitin-like modifier
KIAA0101 KIAA0101
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LUM lumican
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
NREP neuronal regeneration related protein
PCP4 Purkinje cell protein 4
PERP PERP, TP53 apoptosis effector
PLAC8 placenta-specific 8
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCH protein kinase C, eta
RAD51AP1 RAD51 associated protein 1
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
STS steroid sulfatase (microsomal), isozyme S
TACSTD2 tumor-associated calcium signal transducer 2
TOPBP1 topoisomerase (DNA) II binding protein 1
TSPAN6 tetraspanin 6
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UPK1A uroplakin 1A
VAMP8 vesicle-associated membrane protein 8
WFDC2 WAP four-disulfide core domain 2
Funding