BRD-K64890080_BI-2536_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K64890080_BI-2536_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
ANXA4 annexin A4
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C3 complement component 3
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CIRBP cold inducible RNA binding protein
CLU clusterin
CST3 cystatin C
CYBA cytochrome b-245, alpha polypeptide
DDIT4 DNA-damage-inducible transcript 4
DES desmin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ETV1 ets variant 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FZD7 frizzled class receptor 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX3 glutathione peroxidase 3
H2BFS H2B histone family, member S (pseudogene)
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KIF2C kinesin family member 2C
MATN2 matrilin 2
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
NFIL3 nuclear factor, interleukin 3 regulated
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLAU plasminogen activator, urokinase
PLTP phospholipid transfer protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS1 regulator of G-protein signaling 1
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TES testin LIM domain protein
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM45A transmembrane protein 45A
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8
VSIG4 V-set and immunoglobulin domain containing 4
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
C2CD2 C2 calcium-dependent domain containing 2
CA12 carbonic anhydrase XII
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTDNEP1 CTD nuclear envelope phosphatase 1
EGFR epidermal growth factor receptor
GBP2 guanylate binding protein 2, interferon-inducible
GCLM glutamate-cysteine ligase, modifier subunit
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
HBB hemoglobin, beta
HOPX HOP homeobox
IGFBP5 insulin-like growth factor binding protein 5
LIMCH1 LIM and calponin homology domains 1
LRRC17 leucine rich repeat containing 17
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
OPN3 opsin 3
PCDH7 protocadherin 7
PEX11A peroxisomal biogenesis factor 11 alpha
PRKCD protein kinase C, delta
PRKCH protein kinase C, eta
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
SATB1 SATB homeobox 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
TCERG1 transcription elongation regulator 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
WDR82 WD repeat domain 82
XBP1 X-box binding protein 1
Funding