BRD-K65182930_NVP-AUY922_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

208 genes differentially expressed following the BRD-K65182930_NVP-AUY922_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
ASCL1 achaete-scute family bHLH transcription factor 1
AURKA aurora kinase A
B3GNT1
BAG3 BCL2-associated athanogene 3
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBX bobby sox homolog (Drosophila)
BRD8 bromodomain containing 8
C1ORF54 chromosome 1 open reading frame 54
C1QB complement component 1, q subcomponent, B chain
CCDC28A coiled-coil domain containing 28A
CD163 CD163 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHEK2 checkpoint kinase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL3A1 collagen, type III, alpha 1
CTSK cathepsin K
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DENND2D DENN/MADD domain containing 2D
ECHDC2 enoyl CoA hydratase domain containing 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FGFR2 fibroblast growth factor receptor 2
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GBA3 glucosidase, beta, acid 3 (gene/pseudogene)
GLUL glutamate-ammonia ligase
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GOLGB1 golgin B1
HAL histidine ammonia-lyase
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H2BG histone cluster 1, H2bg
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
KIF20A kinesin family member 20A
LAMP3 lysosomal-associated membrane protein 3
LITAF lipopolysaccharide-induced TNF factor
LOC100272216 uncharacterized LOC100272216
LTF lactotransferrin
MUC5B mucin 5B, oligomeric mucus/gel-forming
NARF nuclear prelamin A recognition factor
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NNT nicotinamide nucleotide transhydrogenase
PCDH17 protocadherin 17
PCP4 Purkinje cell protein 4
PDCD6 programmed cell death 6
PDZD8 PDZ domain containing 8
PENK proenkephalin
PFDN5 prefoldin subunit 5
PFKM phosphofructokinase, muscle
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G16 phospholipase A2, group XVI
PROM1 prominin 1
PTK2B protein tyrosine kinase 2 beta
PTOV1 prostate tumor overexpressed 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCAN2 regulator of calcineurin 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
TBC1D15 TBC1 domain family, member 15
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TMEM97 transmembrane protein 97
TNNT1 troponin T type 1 (skeletal, slow)
TPBG trophoblast glycoprotein
TSPAN13 tetraspanin 13
UBE2C ubiquitin-conjugating enzyme E2C
WFS1 Wolfram syndrome 1 (wolframin)
XCL1 chemokine (C motif) ligand 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADAM12 ADAM metallopeptidase domain 12
ADGRG1 adhesion G protein-coupled receptor G1
AFP alpha-fetoprotein
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
ANPEP alanyl (membrane) aminopeptidase
AXL AXL receptor tyrosine kinase
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCL2 chemokine (C-C motif) ligand 2
CD44 CD44 molecule (Indian blood group)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEP170 centrosomal protein 170kDa
CFLAR CASP8 and FADD-like apoptosis regulator
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DENND5A DENN/MADD domain containing 5A
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
DUOX2 dual oxidase 2
EGR1 early growth response 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLIPR1 GLI pathogenesis-related 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KRCC1 lysine-rich coiled-coil 1
LEF1 lymphoid enhancer-binding factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIF leukemia inhibitory factor
LMCD1 LIM and cysteine-rich domains 1
LOX lysyl oxidase
MAP1B microtubule-associated protein 1B
MARCKSL1 MARCKS-like 1
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NOP10 NOP10 ribonucleoprotein
NRCAM neuronal cell adhesion molecule
NT5DC2 5'-nucleotidase domain containing 2
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM2 PDZ and LIM domain 2 (mystique)
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMEPA1 prostate transmembrane protein, androgen induced 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRKCA protein kinase C, alpha
PRSS2 protease, serine, 2 (trypsin 2)
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PUS7 pseudouridylate synthase 7 (putative)
RBP1 retinol binding protein 1, cellular
RFTN1 raftlin, lipid raft linker 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SATB2 SATB homeobox 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERTAD2 SERTA domain containing 2
SFRP1 secreted frizzled-related protein 1
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STK17A serine/threonine kinase 17a
TAGLN2 transgelin 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TMCC1 transmembrane and coiled-coil domain family 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSPAN7 tetraspanin 7
UPP1 uridine phosphorylase 1
VCAN versican
VSNL1 visinin-like 1
WSB2 WD repeat and SOCS box containing 2
Funding